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Proteins/UNIPROT:Q12882
Catalyzes the reduction of uracil and thymine in the initial step of reductive pyrimidine catabolism, a pathway that yields beta-alanine from uracil and beta-aminoisobutyrate from thymine. Also capable of degrading the chemotherapeutic drug 5-fluorouracil..
Function from UniProtKB (Q12882), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
41 statements
41 statements · 6 reference databases · Subject: DPYD · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
5,6-dihydrouracil+NADP(3-)proton+NADPH(4-)+uracil
Catalysed by DPYD
Reaction pageReversibleBalancedEC 1.3.1.2cytosol
Human-GEM MAR04345CC BY 4.0Reference data
proton+NADH(2-)+MAM02997c5,6-dihydrothymine+NAD(+)
Catalysed by DPYD
5 names
Resolves to: DPYD
Human-GEM MAR04470CC BY 4.0Reference data
proton+NADH(2-)+MAM02997m5,6-dihydrothymine+NAD(+)
Catalysed by DPYD
Reaction pageLeft to rightBalancedEC 1.3.1.2mitochondrial matrix
Human-GEM MAR04471CC BY 4.0Reference data
proton+NADPH(4-)+MAM02997c5,6-dihydrothymine+NADP(3-)
Catalysed by DPYD
Reaction pageLeft to rightBalancedEC 1.3.1.2cytosol
Human-GEM MAR04472CC BY 4.0Reference data
5,6-dihydrouracil+NADP(3-)uracil+NADPH(4-)+hydron
Catalysed by DPYD
Reaction pageRight to leftBalanced
Rhea RHEA:18093CC BY 4.0Reference data
5,6-dihydrothymine+NADP(3-)CHEBI:17821+NADPH(4-)+hydron
Catalysed by DPYD
Reaction pageRight to leftBalanced
Rhea RHEA:58284CC BY 4.0Reference data