octadecanoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

898 compounds within 3 steps: 43 in 1, 255 in 2, 600 in 3

Three steps

AReach from here →
1. Stearoyl-CoA hydrolase
2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, mitochondrial matrixOne of 8 routes
(5E)-tetradecenoyl-(R)-carnitineReach from here →
1. Stearoyl-CoA hydrolase
2. Carnitine O-Palmitoyltransferase
3. carnitine O-palmitoyltransferase ((9E)-tetradecenoyl-CoA)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 7 routes
(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 8 more
(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 8 more
(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 5 more
(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 7 more
(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 2 more
(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 6 more
5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 26 morecytosolOne of 4 routes
S-butanoyl-4'-phosphopantetheineReach from here →
1. Stearoyl-CoA hydrolase
2. Butanoate:CoA ligase (AMP-forming)
3. butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
S-octanoyl-4'-phosphopantetheineReach from here →
1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
2. Beta Oxidation Fatty Acid
3. octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by SCD, ACADM, ACADS, NUDT19 and 2 morecytosol, mitochondrial matrix
decanoyl-4'-phosphopantetheineReach from here →
1. Stearoyl-CoA hydrolase
2. medium-chain acyl-CoA ligase (decanoic acid)
3. decanoyl-CoA + H2O = decanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosol
S-dodecanoyl-4'-phosphopantetheineReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol
17-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 26 morecytosolOne of 2 routes
tetradecanoyl-4'-phosphopantetheineReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol
16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 1 more
tauroursodeoxycholateReach from here →
1. Stearoyl-CoA hydrolase
2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
3. taurine to tauroursodeoxycholate conversion
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 2 routes
glycoursodeoxycholateReach from here →
1. Stearoyl-CoA hydrolase
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. glycine to glycoursodeoxycholate conversion
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes
10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 10-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 2 more
leukotriene F4Reach from here →
1. Stearoyl-CoA hydrolase
2. N-acetyl-LTE4 to leukotriene E4 conversion
3. leukotriene F4 hydrolysis
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 33 morecytosol
(8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 1 more
(14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 1 more
2,4-dinitrophenyl-S-glutathioneReach from here →
1. Stearoyl-CoA hydrolase
2. N-acetyl-LTE4 to leukotriene E4 conversion
3. transport of leukotriene E4 (cytosol to extracellular)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 34 morecytosol, extracellular spaceOne of 4 routes
N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
2. Oleoyl-CoA hydrolase
3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O
Catalysed by SCD, ACOT7, BAAT, THEM4 and 3 morecytosol
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 1 more
N-(9Z-octadecenoyl)-L-leucineReach from here →
1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
2. Oleoyl-CoA hydrolase
3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate
Catalysed by SCD, ACOT7, BAAT, THEM4 and 3 morecytosol
N-(9Z-hexadecenoyl)-glycineReach from here →
1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
2. Fatty Acid Beta Oxidation (C18:1->C16:1), Mitochondrial
3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)
Catalysed by SCD, HADHA, ACADVL, HADHB and 1 morecytosol, mitochondrial matrixOne of 2 routes
9-(9Z-octadecenoyloxy)-octadecanoateReach from here →
1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA
3. 9-hydroxy-octadecanoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 9-(9Z-octadecenoyloxy)-octadecanoate + 2-(9Z-octadecenoyl)-glycerol
Catalysed by SCD, SCD5, DGAT1, MOGAT3 and 2 moreOne of 2 routes
7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 26 morecytosolOne of 2 routes
13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 26 morecytosolOne of 2 routes
cholesterol sulfateReach from here →
1. Acyl-CoA:cholesterol O-acyltransferase
2. Steryl-ester acylhydrolase
3. 3'-phosphoadenylyl-sulfate:cholesterol sulfotransferase
Catalysed by SOAT2, SOAT1, CEL, LIPA and 2 moreendoplasmic reticulum, lysosome, cytosolOne of 4 routes
13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 1 more
16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
3. unspecific monooxygenase (arachidonate)
Catalysed by LPGAT1, PLA2G10, PLA2G6, PLA2G4A and 26 morecytosol
(11Z,14Z,17Z-eicosatrienoyl)-cholesterolReach from here →
1. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
2. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
3. 1-hexadecanoyl-2-(11Z,14Z,17Z-eicosatrienoyl)-sn-glycero-3-phosphocholine + cholesterol = (11Z,14Z,17Z-eicosatrienoyl)-cholesterol + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by CERS1, TLCD3B, CERS2, CERS4 and 2 more
2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by LPGAT1, PLA2G15, PTGS2
2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by LPGAT1, PLA2G15, PTGS2
2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by LPGAT1, PLA2G15, PTGS2
2-(prostaglandin G2)-sn-glycero-3-phosphocholineReach from here →
1. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
2. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, PLA2G15, PTGS2
2-hydroxyoctanoyl-CoAReach from here →
1. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)
2. Beta Oxidation Fatty Acid
3. octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2
Catalysed by SCD, ACADM, ACADS, PHYHcytosol, mitochondrial matrix
2-hydroxydecanoyl-CoAReach from here →
1. Stearoyl-CoA hydrolase
2. medium-chain acyl-CoA ligase (decanoic acid)
3. decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosol
2-hydroxyeicosanoyl-CoAReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyeicosanoyl-CoA + succinate + CO2
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
2-hydroxydodecanoyl-CoAReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
2-hydroxytetradecanoyl-CoAReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
11-cis-retinyl tetradecanoateReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. 11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes
9-cis-retinyl tetradecanoateReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. 9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
13-cis-retinyl tetradecanoateReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. 13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
all-trans-retinyl tetradecanoateReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
tetradecyl tetradecanoateReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
1. Stearoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes
2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoate + H(+)
Catalysed by SCD, SCD5, LCLAT1, LPGAT1 and 2 moreOne of 2 routes