3-(4-hydroxyphenyl)pyruvate

Three steps

• 2-hydroxy-4-methylvaleric acidReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine
  3. 4-methyl-2-oxopentanoate reduction

  Catalysed by AADAT, SDR42E2, AKR1B15, AKR1B10 and 15 morecytosol

• dopamineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
  3. L-dopa + H(+) = dopamine + CO2

  Catalysed by TAT, TH, DDC

• N-benzoylglycineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by TAT, AADATmitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by TAT, SLC7A13, SLC25A12, SLC25A13inner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• a 1-(1-hydroxyalkyl)-sn-glycerolReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. 1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by TAT, PAH, AGMO

• (2S)-2-aminobutanoateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by TAT, AADAT, AGXT2One of 6 routes

• 2-iminobutanoateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by AADAT, AGXT2, RIDA

• 3-phenyllactateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. Formation of Phenyl-Lactate

  Catalysed by AADATcytosol

• glycodeoxycholateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. Glycodeoxycholate amidohydrolase

  Catalysed by TAT, AADATcytosolOne of 2 routes

• N-tetradecanoylglycineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

  Catalysed by TAT, AADAT, GLYATL2One of 2 routes

• N-eicosanoylglycinateReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by TAT, AADAT, BAAT

• N-docosanoylglycineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by TAT, AADAT, BAAT

• N-hexacosanoylglycineReach from here →
  1. L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by TAT, AADAT, BAAT

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by AADAT, AGXT, AGXT2, PDHA1 and 2 moremitochondrial matrix