5-hydroxyisourate

Three steps

• S-sulfanylglutathioneReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)

  Catalysed by SLC22A13, ETHE1cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. urate:oxygen oxidoreductase
  2. ascorbate to monodehydroascorbate conversion
  3. 8-peroxy-(5Z,9E,11Z,14Z)... to 5,9-cyclo-6,8-cycloperoxy-12... conversion

  No catalyst recordedcytosolOne of 8 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (2S)-2-phospholactateReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by SLC22A12, SLC22A13, PGPcytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• estrone 3-sulfateReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

  Catalysed by SLC22A8, SLC22A24, SLC22A11cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by SLC22A12, SLC22A13, SLCO2A1cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• N-benzoylglycineReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SLC22A6, SLC22A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-cysteinylglycineReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. glutathione + H2O = L-cysteinylglycine + L-glutamate

  Catalysed by SLC22A13, GGT3P, GGT1, GGT5 and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• ubiquinol-10Reach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by SLC22A13, SQORcytosol, inner side of the membrane, outer side of the membrane

• (R)-noradrenalineReach from here →
  1. urate:oxygen oxidoreductase
  2. ascorbate to monodehydroascorbate conversion
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by DBHcytosol

• NAADP(+)Reach from here →
  1. urate:oxygen oxidoreductase
  2. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)
  3. nicotinate + NADP(+) = NAADP(+) + nicotinamide

  Catalysed by SLC22A12, SLC22A13, CD38cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SLC22A13, GPX1, GPX4cytosol, inner side of the membrane, outer side of the membrane

• 17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →
  1. urate:oxygen oxidoreductase
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SLC22A8, SLC22A24cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycodeoxycholateReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SLC22A13, ABCC4cytosol, inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC22A13, GPX1, GPX2, GPX4cytosol, inner side of the membrane, outer side of the membrane

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC22A13, PTGES, MGST3, GPX1 and 3 morecytosol, inner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC22A13, GPX1, GPX4cytosol, inner side of the membrane, outer side of the membrane

• thromboxane B2Reach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
  3. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

  Catalysed by SLC22A12, SLC22A13, SLCO2A1cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SLC22A13, GSTT4, GSTA4, GSTZ1 and 20 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SLC22A13, GPX1, GSTA1, GPX2 and 1 morecytosol, inner side of the membrane, outer side of the membrane

• taurochenodeoxycholateReach from here →
  1. urate:oxygen oxidoreductase
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SLC22A13, ABCC4cytosol, inner side of the membrane, outer side of the membrane