a cholesterol ester

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

204 compounds within 3 steps: 8 in 1, 47 in 2, 149 in 3

Three steps

beta-D-glucosyl-N-octanoylsphing-4E-enineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreOne of 2 routes
Mo-molybdopterinReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + sn-glycerol 3-phosphocholine
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)
Catalysed by CEL, LIPA, ABHD12lysosome
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)
Catalysed by CEL, LIPA, ABHD16Alysosome
N-(hexadecanoyl)-sphing-4-enine-1-phosphateReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
3. N-hexadecanoylsphing-4-enine + ATP = N-(hexadecanoyl)-sphing-4-enine-1-phosphate + ADP + H(+)
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 4 moreOne of 4 routes
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 6 moreOne of 2 routes
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 4 more
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 3 moreOne of 2 routes
1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
Catalysed by CES1, LIPN, NCEH1, LDAH and 3 more
an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol
Catalysed by CES1, LIPN, NCEH1, LDAH and 5 more
1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine
3. 1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreOne of 2 routes
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. long-chain-fatty-acid-CoA ligase (EPA)
Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 6 morelysosome, cytosolOne of 3 routes
1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 3 more
(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
Catalysed by CEL, LIPA, SLC27A2, ACSL4 and 6 morelysosome, cytosolOne of 2 routes
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. dodecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 3 more
1-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 3 moreOne of 2 routes
1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. decanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. hexanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. octanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerolReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
Catalysed by CEL, LIPA, ABHD11lysosome
1-hexadecanoyl-sn-glycerolReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)
Catalysed by CES1, LIPN, NCEH1, LDAH and 5 more
2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
beta-D-glucosyl-N-dodecanoylsphing-4-enineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreOne of 2 routes
beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreOne of 2 routes
(17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CEL, LIPA, CYP1A1, CYP1A2 and 5 morelysosome
(17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CEL, LIPA, CYP2C8, CYP2D6 and 1 morelysosome
19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. EPA[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate[r]
Catalysed by CEL, LIPA, CYP2E1lysosome, endoplasmic reticulumOne of 3 routes
20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CEL, LIPA, CYP4F2, CYP4F3 and 1 morelysosome
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerolReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)
Catalysed by CEL, LIPA, ABHD11lysosome
1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
(5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoateReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate
Catalysed by CEL, LIPA, ALOX12Blysosome
18-hydroxy-(9Z)-octadecenoateReach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. (9Z)-octadecenoate + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-(9Z)-octadecenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CEL, LIPA, CYP4A11, CYP4F11lysosome
1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
2. Steryl-ester acylhydrolase
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + (9Z)-octadecenoate + H(+)
Catalysed by CEL, LIPA, ABHD12lysosome
hexadecanoateReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)
Catalysed by CES1, LIPN, NCEH1, LDAH and 18 moreOne of 2 routes
7alpha-hydroxypregnenoloneReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
3. pregnenolone,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 morecytosolOne of 2 routes
(24S)-24-hydroxycholesterol esterReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
3. a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + (24S)-hydroxycholesterol = (24S)-24-hydroxycholesterol ester + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
(24S)-hydroxycholesterol 3-linoleoateReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
3. (24S)-hydroxycholesterol + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine = (24S)-hydroxycholesterol 3-linoleoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1,2-dihexadecanoyl-sn-glycerolReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
Catalysed by CES1, LIPN, NCEH1, LDAH and 3 more
1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 more
1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerolReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. 1-(9Z-octadecenoyl)-2-acyl-sn-3-glycerol + a sphingomyelin = a 1-(9Z-octadecenoyl)-2-acyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine
Catalysed by CES1, LIPN, NCEH1, LDAH and 4 more
beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreOne of 2 routes
beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enineReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine
3. beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine
Catalysed by CES1, LIPN, NCEH1, LDAH and 2 moreOne of 2 routes
24S,25-dihydroxycholesterolReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
3. (24S)-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 24S,25-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CES1, LIPN, NCEH1, LDAH and 1 more
(24S,25R)-24,26-dihydroxycholesterolReach from here →
1. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
2. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
3. (24S)-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S,25R)-24,26-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by CES1, LIPN, NCEH1, LDAH and 1 more