1,2-diacyl-sn-glycero-3-phosphocholine(1+)

Three steps

• docosanedioateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Fatty Acid Omega Oxidation by Hydroxylases (C22->C22Dc), Endoplasmatic Reticulum

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 moreendoplasmic reticulum, extracellular space

• dodecanedioyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 moreendoplasmic reticulum, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Production of Suberylcarnitine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 moreendoplasmic reticulum, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 7 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 7 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 5 routes

• 1-O-alkyl-2,3-diacyl-sn-glycerolReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. 1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, PLA2G15Golgi apparatusOne of 2 routes

• (25R)-cholest-5-ene-3beta,26-diolReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. 2 reduced [adrenodoxin] + cholesterol + O2 + 2 H(+) = (25R)-cholest-5-ene-3beta,26-diol + 2 oxidized [adrenodoxin] + H2O

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol

• 24-hydroxytetracosanoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. tetracosanoate + reduced [NADPH--hemoprotein reductase] + O2 = 24-hydroxytetracosanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 moreendoplasmic reticulum, extracellular space

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. arachidonic acid:oxygen 1-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 41 moreendoplasmic reticulum, extracellular space, cytosolOne of 3 routes

• 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space

• 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, extracellular space

• 11-hydroxydodecanoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. lauric acid[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 11-hydroxydodecanoate[r]

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular spaceOne of 3 routes

• (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, extracellular space

• (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 moreendoplasmic reticulum, extracellular space

• 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. EPA[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 19-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate[r]

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular spaceOne of 3 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 moreendoplasmic reticulum, extracellular space

• 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = 22-hydroxy-(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 moreendoplasmic reticulum, extracellular space

• 14-hydroxytetradecanoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. alkane 1-monooxygenase (myristic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 moreendoplasmic reticulum, cytosol, peroxisomeOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 moreendoplasmic reticulum, cytosol, peroxisome

• hexadecanedioyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosolOne of 2 routes

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerolReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphateReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(out) + cholesterol(in) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate(in) + cholesterol(out)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• pristanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. fatty-acid-CoA ligase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 24 moreendoplasmic reticulum, cytosol

• a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + a 2-acyl-sn-glycero-3-phosphocholine = a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, PLAAT1Golgi apparatus

• undecanoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 24 moreendoplasmic reticulum, cytosolOne of 3 routes

• a fatty acyl-CoAReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by PTDSS1, CHDH, PTGS1, PTGS2cytosol

• (9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

  Catalysed by PTDSS1, CHDH, PTGS1, PTGS2cytosol

• N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, extracellular spaceOne of 3 routes

• N-dodecanoyl-(4R)-hydroxysphinganineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. N-dodecanoyl-(4R)-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + dodecanoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space

• (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 moreendoplasmic reticulum, extracellular space

• (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5Z,7Z,8Z,10E,14Z,17Z)-12-hydroperoxyeicosapentaenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space

• N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = hexadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

  Catalysed by SGMS1, SGMS2, PLAAT3, PLAAT1Golgi apparatusOne of 3 routes

• 9-cis-retinolReach from here →
  1. Lecithin Retinol Acyltransferase
  2. carboxylesterase (retinyl-ester)
  3. retinol binding protein (retinol)

  Catalysed by LRAT, CES2, RBP4, LIPF and 19 morecytosolOne of 3 routes

• 18-hydroxy-(9Z)-octadecenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (9Z)-octadecenoate + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-(9Z)-octadecenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 moreendoplasmic reticulum, extracellular space

• N-hexadecanoyl-sphinganine-1-phosphocholineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2Golgi apparatusOne of 2 routes

• N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-(4R)-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2Golgi apparatusOne of 2 routes

• an N-acyl-(4R)-4-hydroxysphinganine-phosphocholineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2Golgi apparatusOne of 2 routes

• N-hexadecanoyl-sphinganine-1-phosphoethanolamineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-sphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2, SELENOI, CEPT1 and 1 moreGolgi apparatusOne of 2 routes

• an N-acylsphinganine-1-phosphoethanolamineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosolOne of 2 routes

• N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. N-hexadecanoyl-(4R)-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-hexadecanoyl-(4R)-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2, SELENOI, CEPT1 and 1 moreGolgi apparatusOne of 2 routes

• an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by SGMS1, SGMS2, SELENOI, CEPT1 and 1 moreGolgi apparatusOne of 2 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + (9Z)-octadecenoate + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space