acetylcholine

Three steps

• (R)-adrenalineReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SLCO1B3, SLCO1A2, PNMTextracellular space, cytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by BCHE, ACHE, CHAT, CPT1A and 2 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 8 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. Acetylcholine aectylhydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by BCHE, ACHE, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosol

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 4 routes

• 1-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 3 routes

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 3 routes

• 4-acetamidobutanalReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-acetylputrescine + H2O = putrescine + acetate
  3. N-Acetylputrescine:oxygen oxidoreductase(deaminating)(flavin-containing)

  Catalysed by BCHE, ACHE, HDAC10, AOC2 and 4 morecytosolOne of 2 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 4 routes

• CHEBI:742324Reach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1B3, SLCO1A2, COMT, LRTOMTextracellular space, cytosol

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 5 routes

• nonadecanoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by BCHE, ACHE, CHAT, SLC27A2 and 7 morecytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by BCHE, ACHE, CHAT, CPT1A and 2 morecytosolOne of 3 routes

• (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by SLCO1B3, SLCO1B1, ALOX12Bextracellular space, cytosol

• (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. Arachidonate:oxygen 8-oxidoreductase

  Catalysed by SLCO1B3, SLCO1B1, ALOX12extracellular space, cytosolOne of 2 routes

• 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerolReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. fatty acid amide hydrolase (arachidonate)

  Catalysed by SLCO1B3, SLCO1B1, FAAHextracellular space, cytosol

• 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 8 routes

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 2 routes

• 1-octadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 5 routes

• 2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-octadecanoyl-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosol

• 1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 9 routes

• 2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosol

• 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 2 routes

• 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 3 routes

• 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosol

• 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosol

• 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosolOne of 3 routes

• 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosol

• 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosol

• 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosol

• 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. Acetylcholine aectylhydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

  Catalysed by BCHE, ACHE, ASAH1, PLA2G15cytosol

• 16alpha,17alpha-dihydroxyprogesteroneReach from here →
  1. Acetylcholine aectylhydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. 17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha,17alpha-dihydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by BCHE, ACHE, CYP17A1cytosol, endoplasmic reticulum

• dodecanedioyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Activation of dodecanedioic acid

  Catalysed by BCHE, ACHE, CHATcytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Production of Sebacoylcarnitine

  Catalysed by BCHE, ACHE, CHAT, CPT1A and 2 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Production of Suberylcarnitine

  Catalysed by BCHE, ACHE, CHAT, CPT1A and 2 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. Acetylcholine aectylhydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by BCHE, ACHE, CHATcytosolOne of 4 routes