(S)-carnitine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

976 compounds within 3 steps: 17 in 1, 214 in 2, 745 in 3

Three steps

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositolReach from here →
1. Utilized Transport
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 moreendoplasmic reticulum, cytosol
1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by CPT2, CPT1A, CPT1B, LCLAT1peroxisome
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosol
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. Utilized Transport
2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. Utilized Transport
2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
3. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosol
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosol
1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
3. 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by CPT2, CPT1A, CPT1B, AGPAT2peroxisome
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
1. Utilized Transport
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
3. 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 9 moreendoplasmic reticulum, cytosol
N-dodecanoylsphing-4-enineReach from here →
1. Carnitine O-Palmitoyltransferase
2. acyl-CoA:sphingosine N-acyltransferase
3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 4 morecytosol, Golgi apparatus
N-tetradecanoylsphing-4-enineReach from here →
1. Carnitine O-Palmitoyltransferase
2. acyl-CoA:sphingosine N-acyltransferase
3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate
Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 3 morecytosol, Golgi apparatus
N-hexadecanoylsphing-4-enineReach from here →
1. Carnitine O-Palmitoyltransferase
2. acyl-CoA:sphingosine N-acyltransferase
3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)
Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 7 morecytosol, Golgi apparatusOne of 3 routes
N-octadecanoylsphing-4-enineReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 10 morecytosolOne of 4 routes
N-eicosanoyl-sphing-4-enineReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosolOne of 2 routes
N-tetracosanoyl-sphing-4-enineReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (lignocerate)
3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosolOne of 2 routes
1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CPT2, CPT1A, CPT1B, PRDX6 and 2 moreperoxisome
1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosol
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CPT2, CPT1A, CPT1B, LPGAT1peroxisomeOne of 2 routes
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 10 morecytosol
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. Utilized Transport
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 9 moreendoplasmic reticulum, cytosol
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by CPT2, CPT1A, CPT1B, LPGAT1peroxisomeOne of 2 routes
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. Utilized Transport
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 moreendoplasmic reticulum, cytosol
(9Z)-octadecen-1-olReach from here →
1. Utilized Transport
2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
3. (9Z)-octadecenoyl-CoA + 2 NADPH + 2 H(+) = (9Z)-octadecen-1-ol + 2 NADP(+) + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 5 moreendoplasmic reticulum, cytosol
(9Z,12Z)-octadecadien-1-olReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
(7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoAReach from here →
1. Utilized Transport
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + malonyl-CoA + H(+) = (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CO2 + CoA
Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 10 moreendoplasmic reticulum, cytosol
3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (EPA)
3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CO2 + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosol
(9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (DPA)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + malonyl-CoA + H(+) = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
3-oxooctacosanyol-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
3. hexacosanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctacosanyol-CoA + CO2 + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosol
3-oxotetracosanoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (behenic acid)
3. very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 14 morecytosolOne of 3 routes
3-oxohexacosanoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (lignocerate)
3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 14 morecytosolOne of 3 routes
1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosol
3-oxo-(11Z)-eicosenoyl-CoAReach from here →
1. Utilized Transport
2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
3. (9Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-eicosenoyl-CoA + CO2 + CoA
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 8 moreendoplasmic reticulum, cytosol
(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 11 morecytosol
(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (linolenate)
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 11 morecytosol
3-oxo-(13Z)-docosenoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
3. (11Z)-eicosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-docosenoyl-CoA + CO2 + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
3-oxo-(15Z)-tetracosenoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
3. (13Z)-docosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(15Z)-tetracosenoyl-CoA + CO2 + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
N-(9Z-octadecenoyl)-sphinganineReach from here →
1. Utilized Transport
2. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate
3. sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)
Catalysed by SLC27A2, ACSL3, ACSL1, ACSBG2 and 6 moreendoplasmic reticulum, cytosol
2-hydroxyhexadecanoyl-CoAReach from here →
1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
3. hexadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyhexadecanoyl-CoA + succinate + CO2
Catalysed by CPT2, CPT1A, CPT1B, PHYHperoxisome
2-hydroxyoctadecanoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosol
N-(15Z-tetracosenoyl)-sphinganineReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (nervonic acid)
3. (15Z)-tetracosenoyl-CoA + sphinganine = N-(15Z-tetracosenoyl)-sphinganine + CoA + H(+)
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
N-tetracosanoyl-heptadecasphing-4-enineReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (lignocerate)
3. heptadecasphing-4-enine + tetracosanoyl-CoA = N-tetracosanoyl-heptadecasphing-4-enine + CoA + H(+)
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
(2E)-hexacosenoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
3. acyl-CoA oxidase (hexacosanoyl-CoA)
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 9 morecytosol, peroxisomeOne of 2 routes
3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoAReach from here →
1. Carnitine O-Palmitoyltransferase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
3. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA
Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 8 morecytosol
(6Z)-hexadecenoyl-CoAReach from here →
1. palmitoyl-CoA:L-carnitine O-palmitoyltransferase
2. (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
3. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
Catalysed by CPT2, CPT1A, CPT1B, FADS2peroxisome