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Proteins/UNIPROT:P54219
[Isoform 1]: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli..
[Isoform 2]: Unable to uptake serotonin..
Function from UniProtKB (P54219), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 4 reference databases · Subject: SLC18A1 · Sources: Human Protein Atlas, Human-GEM, Rhea, WikiPathways
13 reactions
5-hydroxytryptophan+ATP+water5-hydroxytryptophan+ADP+proton+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol, extracellular space
Human-GEM MAR00052CC BY 4.0Reference data
4 names
Resolves to: SLC18A1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00065CC BY 4.0Reference data
ATP+dopamine+waterADP+dopamine+proton+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 2.1.1.6cytosol, extracellular space
Human-GEM MAR00334CC BY 4.0Reference data
ATP+water+histamineADP+proton+histamine+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol, extracellular space
Human-GEM MAR01442CC BY 4.0Reference data
ATP+water+(R)-noradrenalineADP+proton+(R)-noradrenaline+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 2.7.7.18cytosol, extracellular space
Human-GEM MAR01555CC BY 4.0Reference data
2ATP+2water+3histamine2ADP+2proton+3histamine+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07633CC BY 4.0Reference data
35-hydroxytryptophan+2ATP+2water35-hydroxytryptophan+2ADP+2proton+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07634CC BY 4.0Reference data
3CHEBI:28918+2ATP+2water2ADP+3CHEBI:28918+2proton+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07635CC BY 4.0Reference data
2ATP+3dopamine+2water2ADP+3dopamine+2proton+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07636CC BY 4.0Reference data
2ATP+2water+3(R)-noradrenaline2ADP+2proton+3(R)-noradrenaline+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07637CC BY 4.0Reference data
dopamine+2hydrondopamine+2hydron
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalanced
Rhea RHEA:73739CC BY 4.0Reference data
serotonin+2hydronserotonin+2hydron
Transported by SLC18A1 or SLC18A2 or SLC18A3
Reaction pageLeft to rightBalanced
Rhea RHEA:73743CC BY 4.0Reference data