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Proteins/UNIPROT:Q05940
Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules..
Function from UniProtKB (Q05940), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
37 statements
37 statements · 8 reference databases · Subject: SLC18A2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
13 reactions
5-hydroxytryptophan+ATP+water5-hydroxytryptophan+ADP+proton+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol, extracellular space
Human-GEM MAR00052CC BY 4.0Reference data
6 names
Resolves to: SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00065CC BY 4.0Reference data
ATP+dopamine+waterADP+dopamine+proton+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 2.1.1.6cytosol, extracellular space
Human-GEM MAR00334CC BY 4.0Reference data
ATP+water+histamineADP+proton+histamine+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol, extracellular space
Human-GEM MAR01442CC BY 4.0Reference data
ATP+water+(R)-noradrenalineADP+proton+(R)-noradrenaline+phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedEC 2.7.7.18cytosol, extracellular space
Human-GEM MAR01555CC BY 4.0Reference data
2ATP+2water+3histamine2ADP+2proton+3histamine+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07633CC BY 4.0Reference data
35-hydroxytryptophan+2ATP+2water35-hydroxytryptophan+2ADP+2proton+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07634CC BY 4.0Reference data
3CHEBI:28918+2ATP+2water2ADP+3CHEBI:28918+2proton+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07635CC BY 4.0Reference data
2ATP+3dopamine+2water2ADP+3dopamine+2proton+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07636CC BY 4.0Reference data
2ATP+2water+3(R)-noradrenaline2ADP+2proton+3(R)-noradrenaline+2phosphate(3-)
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07637CC BY 4.0Reference data
dopamine+2hydrondopamine+2hydron
Transported by SLC18A1 or SLC18A2
Reaction pageLeft to rightBalanced
Rhea RHEA:73739CC BY 4.0Reference data
serotonin+2hydronserotonin+2hydron
Transported by SLC18A1 or SLC18A2 or SLC18A3
Reaction pageLeft to rightBalanced
Rhea RHEA:73743CC BY 4.0Reference data