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Proteins/UNIPROT:P51160
Catalytic alpha subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP as part of the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic alpha subunits (PDE6C) and two inhibitory gamma subunits (PDE6H). Light-activated GNAT2 relieves gamma subunit-mediated inhibition, allowing the catalytic subunits to hydrolyze cGMP and mediate visual signal transduction and amplification. The resulting decrease in cytosolic cGMP levels triggers the closure of cGMP-gated cation channels at the plasma membrane, leading to hyperpolarization of cone photoreceptors (By similarity). The catalytic site can adopt partially open conformations even in the inhibited state, contributing to the higher basal activity and rapid response kinetics characteristic of cones compared to rods..
Function from UniProtKB (P51160), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
9 statements
9 statements · 5 reference databases · Subject: PDE6C · Sources: gene ontology, Human-GEM, Rhea, UniProt, WikiPathways
5 reactions
2 names
Resolves to: PDE6C
Human-GEM MAR04014CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE8A or PDE6C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H and 7 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17, 3.1.4.35cytosol
Human-GEM MAR04048CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE6C or PDE4C or PDE10A or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H or PDE3B and 7 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.35nucleus
Human-GEM MAR08083CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE8A or PDE6C or PDE4C or PDE10A or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H and 6 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17Golgi apparatus
Human-GEM MAR08085CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+hydron
Catalysed by PDE2A or PDE5A or PDE9A or PDE6A or PDE6B or PDE6C or PDE1A or PDE1B or PDE3B or PDE6H or PDE1C or PDE3A and 3 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:16957CC BY 4.0Reference data