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Proteins/UNIPROT:Q86TP1
Exopolyphosphatase that catalyzes the hydrolysis of inorganic polyphosphates, with preference for short-chain substrates, as well as nucleoside 5'-tetraphosphates, releasing terminal phosphate residues. Also exhibits phosphodiesterase activity toward cyclic nucleotides, hydrolyzing cAMP and cGMP to their corresponding 5'-monophosphates. Requires divalent metal ions for activity. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization..
Function from UniProtKB (Q86TP1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
84 statements
84 statements · 4 reference databases · Subject: PRUNE1 · Sources: gene ontology, Hetionet, Rhea, UniProt
9 reactions
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by LHPP or PPA2 or PRUNE1 or PPA1
Reaction pageLeft to rightBalancedEC 3.6.1.1endoplasmic reticulum
Human-GEM MAR03975CC BY 4.0Reference data
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by
8 names
Resolves to: PRUNE1
Reaction pageLeft to rightBalancedEC 3.6.1.1cytosol
Human-GEM MAR03977CC BY 4.0Reference data
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by LHPP or PPA2 or PRUNE1 or PPA1
Reaction pageLeft to rightBalancedEC 3.6.1.1peroxisome
Human-GEM MAR03979CC BY 4.0Reference data
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by LHPP or PPA2 or PRUNE1 or PPA1
Reaction pageLeft to rightBalancedEC 3.6.1.1mitochondrial matrix
Human-GEM MAR06912CC BY 4.0Reference data
water+diphosphate(3-)proton+2phosphate(3-)
Catalysed by LHPP or PPA2 or PRUNE1 or PPA1
Reaction pageLeft to rightBalancedEC 3.6.1.1nucleus
Human-GEM MAR07794CC BY 4.0Reference data
triphosphate+waterhydrogenphosphate+diphosphate(3-)
Catalysed by PRUNE1
Reaction pageLeft to rightBalanced
Rhea RHEA:14157CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+hydron
Catalysed by PDE2A or PDE5A or PDE9A or PDE6A or PDE6B or PDE6C or PDE1A or PDE1B or PDE3B or PDE6H or PDE1C or PDE3A and 3 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:16957CC BY 4.0Reference data
adenosine 5'-tetraphosphate+waterhydrogenphosphate+ATP(4-)+hydron
Catalysed by PRUNE1
Reaction pageLeft to rightBalanced
Rhea RHEA:24500CC BY 4.0Reference data
3',5'-cyclic AMP+waterAMP+hydron
Catalysed by PDE2A or PDE8A or PDE8B or ENPP1 or PDE4A or PDE1A or PDE1B or PDE4B or PDE4C or PDE4D or PDE3B or PDE7A and 6 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:25277CC BY 4.0Reference data