Proteins/UNIPROT:Q14123

PDE1C

ProteinUNIPROT:Q14123Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). In kidney juxtaglomerular granular cells, inhibits renin release by decreasing cAMP levels (By similarity)..

Function from UniProtKB (Q14123), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

autosomal dominant nonsyndromic hearing loss has a germline basis in PDE1CDiseaseGenCC HGNC:8776|MONDO:0019587Inferred only

Statements

29 statements

29 statements · 7 reference databases · Subject: PDE1C · Sources: Bgee, gene ontology, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Order

PDE1C is expressed in corpus callosumAnatomyBgee ENSG00000154678Inferred only
PDE1C is expressed in endothelial cellCell typeBgee ENSG00000154678Inferred only
PDE1C is expressed in heart right ventricleAnatomyBgee ENSG00000154678Inferred only
PDE1C participates in Ca-dependent eventsPathwayReactome R-HSA-111996Inferred only
PDE1C participates in Calmodulin induced eventsPathwayReactome R-HSA-111933Inferred only
PDE1C participates in CaM pathwayPathwayReactome R-HSA-111997Inferred only
PDE1C participates in Cam-PDE 1 activationPathwayReactome R-HSA-111957Inferred only
PDE1C participates in DAG and IP3 signalingPathwayReactome R-HSA-1489509Inferred only
PDE1C participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
PDE1C participates in G protein signalingPathwayWikiPathways WP35Inferred only
PDE1C participates in G-protein mediated eventsPathwayReactome R-HSA-112040Inferred only
PDE1C participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only

Show the remaining 17

PDE1C participates in Intracellular signaling by second messengersPathwayReactome R-HSA-9006925Inferred only
PDE1C participates in Opioid SignallingPathwayReactome R-HSA-111885Inferred only
PDE1C participates in Phosphodiesterases in neuronal functionPathwayWikiPathways WP4222Inferred only
PDE1C participates in PLC beta mediated eventsPathwayReactome R-HSA-112043Inferred only
PDE1C participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PDE1C participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
PDE1C regulates negative regulation of cAMP/PKA signal transductionBiological processgene ontology Q14123|GO:0141162Inferred only
PDE1C regulates negative regulation of renin secretion into blood streamBiological processgene ontology Q14123|GO:1900134Inferred only
PDE1C requires the cofactor magnesium(2+)CompoundUniProt Q14123Inferred only
PDE1C requires the cofactor Zn(2+)CompoundUniProt Q14123Inferred only
3',5'-cyclic AMP is a substrate of PDE1CCompoundHuman-GEM MAR04014Inferred only
3',5'-cyclic AMP is a substrate of PDE1CCompoundHuman-GEM MAR08087Inferred only
3',5'-cyclic AMP is a substrate of PDE1CCompoundRhea RHEA:25277Inferred only
3',5'-cyclic GMP is a substrate of PDE1CCompoundHuman-GEM MAR04048Inferred only
3',5'-cyclic GMP is a substrate of PDE1CCompoundRhea RHEA:16957Inferred only
3',5'-cyclic GMP is a substrate of PDE1CCompoundHuman-GEM MAR08085Inferred only
3',5'-cyclic GMP is a substrate of PDE1CCompoundHuman-GEM MAR08083Inferred only

Reactions

8 reactions

3',5'-cyclic AMP+waterAMP+proton
Catalysed by PDE4A or PDE8A or PDE6C or PDE4C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6H or PDE3B and 7 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17

Other names

2 names

Resolves to: PDE1C

Also called: Cam-PDE 1CHcam3

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cytosol

Human-GEM MAR04014CC BY 4.0Reference data

3',5'-cyclic GMP+waterGMP+proton

Catalysed by PDE8A or PDE6C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H and 7 more alternatives

Reaction pageLeft to rightBalancedEC 3.1.4.17, 3.1.4.35cytosol

Human-GEM MAR04048CC BY 4.0Reference data

3',5'-cyclic GMP+waterGMP+proton

Catalysed by PDE6C or PDE4C or PDE10A or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H or PDE3B and 7 more alternatives

Reaction pageLeft to rightBalancedEC 3.1.4.35nucleus

Human-GEM MAR08083CC BY 4.0Reference data

3',5'-cyclic GMP+waterGMP+proton

Catalysed by PDE8A or PDE6C or PDE4C or PDE10A or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H and 6 more alternatives

Reaction pageLeft to rightBalancedEC 3.1.4.17Golgi apparatus

Human-GEM MAR08085CC BY 4.0Reference data

3',5'-cyclic AMP+waterAMP+proton

Catalysed by PDE4A or PDE8A or PDE4C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6H or PDE3B or PDE1C and 6 more alternatives

Reaction pageLeft to rightBalancedEC 3.1.4.17Golgi apparatus

Human-GEM MAR08087CC BY 4.0Reference data

CHEBI:58464+waterCHEBI:57867+hydron

Catalysed by PDE2A or PDE1A or PDE1B or PDE3B or PDE1C or PDE3A or PDE10A

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:14653CC BY 4.0Reference data

3',5'-cyclic GMP+waterGMP+hydron

Catalysed by PDE2A or PDE5A or PDE9A or PDE6A or PDE6B or PDE6C or PDE1A or PDE1B or PDE3B or PDE6H or PDE1C or PDE3A and 3 more alternatives

Reaction pageLeft to rightBalanced

Rhea RHEA:16957CC BY 4.0Reference data

3',5'-cyclic AMP+waterAMP+hydron

Catalysed by PDE2A or PDE8A or PDE8B or ENPP1 or PDE4A or PDE1A or PDE1B or PDE4B or PDE4C or PDE4D or PDE3B or PDE7A and 6 more alternatives

Reaction pageLeft to rightBalanced

Rhea RHEA:25277CC BY 4.0Reference data