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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed

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Atlas Graph Access Compounds Outcomes Proteins Interactions Papers Articles Pathways Processes Anatomy Cell types Organisms Materials Assessments

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Catalyst

The evidence graph for human biochemistry. Every edge carries its source, its study design, and a grade computed from both.

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Reference layer

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Anatomy
Cell types
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Materials
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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Reaction

3',5'-cyclic GMP+waterGMP+proton

Left to right · Balanced · EC 3.1.4.17, 3.1.4.35

Compartment: GO:0005829

Inferred

Reference data, not a finding. Evidence key

Catalysts

PDE8A
PDE6C
PDE10A
PDE8B
PDE4D
PDE1A
PDE1B
PDE11A
PDE6A
PDE6B
PDE5A
PDE6H
PDE3B
PDE1C
PDE9A
PDE7B
PDE3A
PDE6G
PDE2A

Human-GEM MAR04048·2.0.1·CC BY 4.0Reference data