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Proteins/UNIPROT:O60658
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine..
Function from UniProtKB (O60658), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
34 statements
34 statements · 8 reference databases · Subject: PDE8A · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
5 reactions
1 name
Resolves to: PDE8A
Human-GEM MAR04014CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE8A or PDE6C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H and 7 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17, 3.1.4.35cytosol
Human-GEM MAR04048CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE8A or PDE6C or PDE4C or PDE10A or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H and 6 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17Golgi apparatus
Human-GEM MAR08085CC BY 4.0Reference data
3',5'-cyclic AMP+waterAMP+proton
Catalysed by PDE4A or PDE8A or PDE4C or PDE10A or PDE8B or PDE4D or PDE1A or PDE1B or PDE11A or PDE6H or PDE3B or PDE1C and 6 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17Golgi apparatus
Human-GEM MAR08087CC BY 4.0Reference data
3',5'-cyclic AMP+waterAMP+hydron
Catalysed by PDE2A or PDE8A or PDE8B or ENPP1 or PDE4A or PDE1A or PDE1B or PDE4B or PDE4C or PDE4D or PDE3B or PDE7A and 6 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:25277CC BY 4.0Reference data