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Proteins/UNIPROT:P35913
Catalytic beta subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (Probable). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (By similarity)..
Function from UniProtKB (P35913), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
19 statements
19 statements · 7 reference databases · Subject: PDE6B · Sources: gene ontology, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
2 names
Resolves to: PDE6B
Human-GEM MAR04048CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE6C or PDE4C or PDE10A or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H or PDE3B and 7 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.35nucleus
Human-GEM MAR08083CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+proton
Catalysed by PDE8A or PDE6C or PDE4C or PDE10A or PDE4D or PDE1A or PDE1B or PDE11A or PDE6A or PDE6B or PDE5A or PDE6H and 6 more alternatives
Reaction pageLeft to rightBalancedEC 3.1.4.17Golgi apparatus
Human-GEM MAR08085CC BY 4.0Reference data
3',5'-cyclic GMP+waterGMP+hydron
Catalysed by PDE2A or PDE5A or PDE9A or PDE6A or PDE6B or PDE6C or PDE1A or PDE1B or PDE3B or PDE6H or PDE1C or PDE3A and 3 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:16957CC BY 4.0Reference data