Proteins/UNIPROT:O75915

ARL6IP5

ProteinUNIPROT:O75915

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum..

Function from UniProtKB (O75915), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

35 statements

35 statements · 3 reference databases · Subject: ARL6IP5 · Sources: gene ontology, Hetionet, Reactome

Order

ARL6IP5 covaries with ANKRD52ProteinHetionet hetionet:covaries:10550-283373Inferred only
TMLHE covaries with ARL6IP5ProteinHetionet hetionet:covaries:10550-55217Inferred only
TRAPPC4 covaries with ARL6IP5ProteinHetionet hetionet:covaries:10550-51399Inferred only
ZNF300 covaries with ARL6IP5ProteinHetionet hetionet:covaries:10550-91975Inferred only
ARL6IP5 covaries with ZNF524ProteinHetionet hetionet:covaries:10550-147807Inferred only
ARL6IP5 interacts with ARL6ProteinHetionet hetionet:interacts:10550-84100Inferred only
CCR5 interacts with ARL6IP5ProteinHetionet hetionet:interacts:10550-1234Inferred only
CLN8 interacts with ARL6IP5ProteinHetionet hetionet:interacts:10550-2055Inferred only
ARL6IP5 interacts with PRAF2ProteinHetionet hetionet:interacts:10550-11230Inferred only
SLC1A1 interacts with ARL6IP5ProteinHetionet hetionet:interacts:10550-6505Inferred only
UBC interacts with ARL6IP5ProteinHetionet hetionet:interacts:10550-7316Inferred only
UBL4A interacts with ARL6IP5ProteinHetionet hetionet:interacts:10550-8266Inferred only

Show the remaining 23

ARL6IP5 interacts with VKORC1ProteinHetionet hetionet:interacts:10550-79001Inferred only
XRCC1 interacts with ARL6IP5ProteinHetionet hetionet:interacts:10550-7515Inferred only
ARL6IP5 participates in Glutamate Neurotransmitter Release CyclePathwayReactome R-HSA-210500Inferred only
ARL6IP5 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
ARL6IP5 participates in Neurotransmitter release cyclePathwayReactome R-HSA-112310Inferred only
ARL6IP5 participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
ARL6IP5 regulates negative regulation of L-glutamate import across plasma membraneBiological processgene ontology O75915|GO:0002037Inferred only
ARL6IP5 regulates negative regulation of mitochondrial membrane potentialBiological processgene ontology O75915|GO:0010917Inferred only
ARL6IP5 regulates negative regulation of transportBiological processgene ontology O75915|GO:0051051Inferred only
ARL6IP5 regulates positive regulation of apoptotic processBiological processgene ontology O75915|GO:0043065Inferred only
ARL6IP5 regulates positive regulation of stress-activated MAPK cascadeBiological processgene ontology O75915|GO:0032874Inferred only
DHRS7 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:51635-10550Inferred only
FADD decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:8772-10550Inferred only
HACD1 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:9200-10550Inferred only
KCNK1 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:3775-10550Inferred only
KIF11 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:3832-10550Inferred only
MTSS1 increases the expression of ARL6IP5ProteinHetionet hetionet:regulates:9788-10550Inferred only
NUDT9 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:53343-10550Inferred only
POP4 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:10775-10550Inferred only
RPS13 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:6207-10550Inferred only
RPS14 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:6208-10550Inferred only
TXNRD1 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:7296-10550Inferred only
XPNPEP1 decreases the expression of ARL6IP5ProteinHetionet hetionet:regulates:7511-10550Inferred only

Other names

15 names

Resolves to: ARL6IP5

Also called: ADP-ribosylation factor-like protein 6-interacting protein 5Aip-5ARL-6-interacting protein 5Cytoskeleton-related vitamin A-responsive proteinDermal papilla-derived protein 11DERP11Glutamate transporter EAAC1-interacting proteinGTRAP3-18JM5JWAPRA2PRAF3Prenylated Rab acceptor protein 2Protein JWaPutative MAPK-activating protein PM27

← Every protein Find it in the graph →