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Proteins/UNIPROT:P08034

GJB1

Protein·UNIPROT:P08034

Open in the graph

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Function from UniProtKB (P08034), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

Charcot-Marie-Tooth disease X-linked dominant 1 has a germline basis in GJB1DiseaseGenCC HGNC:4283|MONDO:0010549Inferred only
X-linked progressive cerebellar ataxia has a germline basis in GJB1DiseaseGenCC HGNC:4283|MONDO:0010547Inferred only

Statements

30 statements

30 statements · 3 reference databases · Subject: GJB1 · Sources: Hetionet, Reactome, WikiPathways

Search this listOrder

CXCR3 covaries with GJB1ProteinHetionet hetionet:covaries:2705-2833Inferred only
GJB1 covaries with H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12ProteinHetionet hetionet:covaries:2705-8357Inferred only
GJB1 covaries with RBM17ProteinHetionet hetionet:covaries:2705-84991Inferred only
APP interacts with GJB1ProteinHetionet hetionet:interacts:2705-351Inferred only
CALM1 interacts with GJB1ProteinHetionet hetionet:interacts:2705-808Inferred only
CALM1 interacts with GJB1ProteinHetionet hetionet:interacts:2705-805Inferred only
CALM1 interacts with GJB1ProteinHetionet hetionet:interacts:2705-801Inferred only
CAV1 interacts with GJB1ProteinHetionet hetionet:interacts:2705-857Inferred only
GJB1 interacts with CNSTProteinHetionet hetionet:interacts:163882-2705Inferred only
GJB1 interacts with GJB2ProteinHetionet hetionet:interacts:2705-2706Inferred only
GJB1 interacts with JUPProteinHetionet hetionet:interacts:2705-3728Inferred only
GJB1 interacts with OCLNProteinHetionet hetionet:interacts:100506658-2705Inferred only

Show the remaining 18

GJB1 interacts with PRKACAProteinHetionet hetionet:interacts:2705-5566Inferred only
GJB1 interacts with PRKCAProteinHetionet hetionet:interacts:2705-5578Inferred only
GJB1 interacts with SRCProteinHetionet hetionet:interacts:2705-6714Inferred only
GJB1 interacts with UBCProteinHetionet hetionet:interacts:2705-7316Inferred only
GJB1 interacts with VKORC1ProteinHetionet hetionet:interacts:2705-79001Inferred only
GJB1 participates in Calcium regulation in cardiac cellsPathwayWikiPathways WP536Inferred only
GJB1 participates in Common pathways underlying drug addictionPathwayWikiPathways WP2636Inferred only
GJB1 participates in Gap junction assemblyPathwayReactome R-HSA-190861Inferred only
GJB1 participates in Gap junction traffickingPathwayReactome R-HSA-190828Inferred only
GJB1 participates in Gap junction trafficking and regulationPathwayReactome R-HSA-157858Inferred only
GJB1 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
GJB1 participates in Neural crest differentiationPathwayWikiPathways WP2064Inferred only
GJB1 participates in Oligomerization of connexins into connexonsPathwayReactome R-HSA-190704Inferred only
GJB1 participates in Transport of connexins along the secretory pathwayPathwayReactome R-HSA-190827Inferred only
GJB1 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
FOXJ3 increases the expression of GJB1ProteinHetionet hetionet:regulates:22887-2705Inferred only
PLPP3 increases the expression of GJB1ProteinHetionet hetionet:regulates:8613-2705Inferred only
SPP1 increases the expression of GJB1ProteinHetionet hetionet:regulates:6696-2705Inferred only

Other names

3 names

Resolves to: GJB1

Also called: Connexin-32CX32GAP junction 28 kDa liver protein

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