Pathway
Degradation of AXIN
AXIN is present in low concentrations in the cell and is considered to be the limiting component of the beta-catenin destruction complex in Xenopus; this may not be the case in mammalian cells, however. Cellular levels of AXIN are regulated in part through ubiquitin-mediated turnover. E3 ligases SMURF2 and RNF146 have both been shown to play a role in promoting the degradation of AXIN by the 26S proteasome.
REACT:R-HSA-4641257Reactome
What the reference databases state
Statements
42 statements
42 statements · 1 reference database · Subject: Degradation of AXIN · Sources: Reactome
- ADRM1 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- AXIN1 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- AXIN2 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMA1 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMA2 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMA3 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMA4 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMA5 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMA6 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMA7 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMB1 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMB2 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
Show the remaining 30
- PSMB3 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMB4 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMB5 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMB6 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMB7 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMC1 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMC2 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMC3 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMC4 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMC5 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMC6 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD1 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD11 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD12 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD13 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD14 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD2 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD3 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD6 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD7 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- PSMD8 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- RNF146 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- RPS27A participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- SEM1 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- SMURF2 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- TNKS participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- TNKS2 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- UBA52 participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- UBB participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only
- UBC participates in Degradation of AXINProteinReactome R-HSA-4641257Inferred only