Pathway
XAV939 stabilizes AXIN
XAV939 binds to the catalytic sites of tankyrase 1 and 2 and inhibits the ADP-ribosylation of AXIN1 and 2. Treatment of cells with XAV939 significantly increases the protein, but not the mRNA levels of AXIN1 and 2 and supports a strong increase in the level of GSK3beta-AXIN complexes. These cells also show increased phosphorylation of beta-catenin, decreased beta-catenin protein levels and a corresponding decrease in beta-catenin dependent transcription. Treatment of DLD-1 cells with XAV939 has also been shown to inhibit proliferation. XAV939 has not been tested in a clinical setting.
REACT:R-HSA-5545619Reactome
What the reference databases state
Statements
2 statements
2 statements · 1 reference database · Subject: XAV939 stabilizes AXIN · Sources: Reactome
- TNKS participates in XAV939 stabilizes AXINProteinReactome R-HSA-5545619Inferred only
- TNKS2 participates in XAV939 stabilizes AXINProteinReactome R-HSA-5545619Inferred only