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Proteins/UNIPROT:Q8TED1
Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and protects the cytosol from ER-derived H(2)O(2). Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation. Modulates endoplasmic reticulum Ca(2+) levels mainly through SERCA pump activity and partially by influencing passive Ca(2+) leakage..
Function from UniProtKB (Q8TED1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 3 reference databases · Subject: GPX8 · Sources: Hetionet, Human-GEM, Reactome
11 reactions
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9cytosol
Human-GEM MAR00960CC BY 4.0Reference data
2 names
Resolves to: GPX8
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9mitochondrial matrix
Human-GEM MAR00963CC BY 4.0Reference data
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+glutathione disulfide+water15(S)-HPETE+2CHEBI:16856
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9cytosol
Human-GEM MAR00988CC BY 4.0Reference data
12(S)-HPETEMAM02096c
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9cytosol
Human-GEM MAR01043CC BY 4.0Reference data
12(S)-HPETEMAM02096e
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9extracellular space
Human-GEM MAR01045CC BY 4.0Reference data
12(S)-HPETEMAM02096x
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9peroxisome
Human-GEM MAR01048CC BY 4.0Reference data
12(S)-HPETEMAM02096r
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9endoplasmic reticulum
Human-GEM MAR01049CC BY 4.0Reference data
(13S)-hydroperoxy-(9Z,11E)-octadecadienoate+proton+NADPH(4-)(13S)-hydroxy-(9Z,11E)-octadecadienoate+water+NADP(3-)
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9cytosol
Human-GEM MAR02441CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or PRDX3 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 and 1 more alternative
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29cytosol
Human-GEM MAR04116CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29extracellular space
Human-GEM MAR04120CC BY 4.0Reference data
2CHEBI:16856+hydrogen peroxideglutathione disulfide+2water
Catalysed by GPX7 or PRDX1 or PRDX6 or PRDX5 or GPX8 or PRDX3 or GPX4 or PRDX2 or GPX2 or GPX6 or GPX3 or GPX5 and 1 more alternative
Reaction pageLeft to rightBalancedEC 1.11.1.9, 1.11.1.24, 1.11.1.25, 1.11.1.26, 1.11.1.27, 1.11.1.28, 1.11.1.29mitochondrial matrix
Human-GEM MAR04121CC BY 4.0Reference data