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Proteins/UNIPROT:O94766
Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation..
Function from UniProtKB (O94766), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
58 statements
58 statements · 6 reference databases · Subject: B3GAT3 · Sources: Bgee, gene ontology, Hetionet, Reactome, UniProt, WikiPathways
2 reactions
MAM01906g+UDP-alpha-D-glucuronateMAM00762g+proton+UDP
Catalysed by B3GAT1 or B3GAT2 or B3GAT3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.135Golgi apparatus
Human-GEM MAR07205CC BY 4.0Reference data
3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein]+UDP-alpha-D-glucuronate3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]+UDP
5 names
Resolves to: B3GAT3
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24168CC BY 4.0Reference data