Proteins/UNIPROT:Q6ZSJ9

SHISA6

ProteinUNIPROT:Q6ZSJ9

Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway..

Function from UniProtKB (Q6ZSJ9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 2 reference databases · Subject: SHISA6 · Sources: gene ontology, Hetionet

Order

SHISA6 covaries with COX6A2ProteinHetionet hetionet:covaries:1339-388336Inferred only
SHISA6 covaries with DTX3ProteinHetionet hetionet:covaries:196403-388336Inferred only
GABBR1 covaries with SHISA6ProteinHetionet hetionet:covaries:2550-388336Inferred only
SHISA6 covaries with GLTPD2ProteinHetionet hetionet:covaries:388323-388336Inferred only
MFHAS1 covaries with SHISA6ProteinHetionet hetionet:covaries:388336-9258Inferred only
MYOCD covaries with SHISA6ProteinHetionet hetionet:covaries:388336-93649Inferred only
NAT14 covaries with SHISA6ProteinHetionet hetionet:covaries:388336-57106Inferred only
SHISA6 covaries with NDNProteinHetionet hetionet:covaries:388336-4692Inferred only
RPS4X covaries with SHISA6ProteinHetionet hetionet:covaries:388336-6191Inferred only
SHISA6 covaries with S100A5ProteinHetionet hetionet:covaries:388336-6276Inferred only
SHISA6 covaries with SFRP5ProteinHetionet hetionet:covaries:388336-6425Inferred only
SIX5 covaries with SHISA6ProteinHetionet hetionet:covaries:147912-388336Inferred only

Show the remaining 3

SHISA6 regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q6ZSJ9|GO:0090090Inferred only
SHISA6 regulates regulation of AMPA glutamate receptor clusteringBiological processgene ontology Q6ZSJ9|GO:1904717Inferred only
SHISA6 regulates regulation of short-term neuronal synaptic plasticityBiological processgene ontology Q6ZSJ9|GO:0048172Inferred only

Other names

2 names

Resolves to: SHISA6

Also called: Protein shisa-6shisa-6

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