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Proteins/UNIPROT:Q9BYE7
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity..
Function from UniProtKB (Q9BYE7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
72 statements
72 statements · 3 reference databases · Subject: PCGF6 · Sources: gene ontology, Hetionet, Reactome
4 names
Resolves to: PCGF6