Proteins/UNIPROT:Q6UX01

LMBR1L

ProteinUNIPROT:Q6UX01

Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis..

Function from UniProtKB (Q6UX01), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

12 statements

12 statements · 2 reference databases · Subject: LMBR1L · Sources: gene ontology, Hetionet

Order

BRSK1 covaries with LMBR1LProteinHetionet hetionet:covaries:55716-84446Inferred only
DTX3 covaries with LMBR1LProteinHetionet hetionet:covaries:196403-55716Inferred only
GAL3ST2 covaries with LMBR1LProteinHetionet hetionet:covaries:55716-64090Inferred only
HAPSTR1 covaries with LMBR1LProteinHetionet hetionet:covaries:29035-55716Inferred only
LMBR1L covaries with NCDNProteinHetionet hetionet:covaries:23154-55716Inferred only
LMBR1L covaries with RABEP2ProteinHetionet hetionet:covaries:55716-79874Inferred only
SOX4 covaries with LMBR1LProteinHetionet hetionet:covaries:55716-6659Inferred only
TCEAL5 covaries with LMBR1LProteinHetionet hetionet:covaries:340543-55716Inferred only
LMBR1L covaries with VAMP8ProteinHetionet hetionet:covaries:55716-8673Inferred only
LCN1 interacts with LMBR1LProteinHetionet hetionet:interacts:3933-55716Inferred only
SCGB1A1 interacts with LMBR1LProteinHetionet hetionet:interacts:55716-7356Inferred only
LMBR1L regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q6UX01|GO:0090090Inferred only

Other names

4 names

Resolves to: LMBR1L

Also called: KIAA1174Limb region 1 protein homolog-likeLIMRLipocalin-1-interacting membrane receptor

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