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Proteins/UNIPROT:P22894

MMP8

Protein·UNIPROT:P22894

Open in the graph

Can degrade fibrillar type I, II, and III collagens.

Function from UniProtKB (P22894), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

30 statements

30 statements · 5 reference databases · Subject: MMP8 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

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ADH7 covaries with MMP8ProteinHetionet hetionet:covaries:131-4317Inferred only
MMP8 covaries with MUC6ProteinHetionet hetionet:covaries:4317-4588Inferred only
OR7G3 covaries with MMP8ProteinHetionet hetionet:covaries:390883-4317Inferred only
ACAN interacts with MMP8ProteinHetionet hetionet:interacts:176-4317Inferred only
MMP8 interacts with BCANProteinHetionet hetionet:interacts:4317-63827Inferred only
MMP8 interacts with CCL2ProteinHetionet hetionet:interacts:4317-6347Inferred only
COL1A2 interacts with MMP8ProteinHetionet hetionet:interacts:1278-4317Inferred only
MMP8 interacts with CXCL5ProteinHetionet hetionet:interacts:4317-6374Inferred only
CXCL8 interacts with MMP8ProteinHetionet hetionet:interacts:3576-4317Inferred only
MMP8 interacts with TFPIProteinHetionet hetionet:interacts:4317-7035Inferred only
MMP8 interacts with TIMP2ProteinHetionet hetionet:interacts:4317-7077Inferred only
MMP8 interacts with UBCProteinHetionet hetionet:interacts:4317-7316Inferred only

Show the remaining 18

MMP8 interacts with UMODProteinHetionet hetionet:interacts:4317-7369Inferred only
MMP8 participates in Activation of Matrix MetalloproteinasesPathwayReactome R-HSA-1592389Inferred only
MMP8 participates in Chronic hyperglycemia impairment of neuron functionPathwayWikiPathways WP5283Inferred only
MMP8 participates in Collagen degradationPathwayReactome R-HSA-1442490Inferred only
MMP8 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
MMP8 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
MMP8 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
MMP8 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
MMP8 participates in Matrix metalloproteinasesPathwayWikiPathways WP129Inferred only
MMP8 participates in Neural crest cell migration during developmentPathwayWikiPathways WP4564Inferred only
MMP8 participates in Neural crest cell migration in cancerPathwayWikiPathways WP4565Inferred only
MMP8 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
MMP8 regulates positive regulation of microglial cell activationBiological processgene ontology P22894|GO:1903980Inferred only
MMP8 regulates positive regulation of neuroinflammatory responseBiological processgene ontology P22894|GO:0150078Inferred only
MMP8 regulates positive regulation of tumor necrosis factor productionBiological processgene ontology P22894|GO:0032760Inferred only
MMP8 regulates positive regulation of tumor necrosis factor-mediated signaling pathwayBiological processgene ontology P22894|GO:1903265Inferred only
MMP8 requires the cofactor Ca(2+)CompoundUniProt P22894Inferred only
MMP8 requires the cofactor Zn(2+)CompoundUniProt P22894Inferred only

Other names

5 names

Resolves to: MMP8

Also called: CLG1Matrix metalloproteinase-8MMP-8PMNL collagenasePMNL-CL

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