CFAP100

Microtubule-associated protein that promotes microtubule polymerization and regulates microtubule organization. Plays a critical role in ensuring proper epidermal development and function by regulating mitosis in keratinocytes. Maintains spindle pole integrity during keratinocyte division through the recruitment of the microtubule glutamylase TTLL13 to spindle poles, thereby enhancing localized microtubule glutamylation. This modification stabilizes spindle microtubules, ensuring accurate spindle assembly, faithful chromosome segregation, and efficient mitotic progression. May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm..

Function from UniProtKB (Q494V2), read 2026-09-23. CC BY 4.0.