(2E,9Z)-hexadecadienoyl-CoA

Three steps

• 1-O-alkyl-3-acylglycerolReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by ACOX3, ACOX1, MOGAT2, AWAT2peroxisome, cytosol

• dodecanedioyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. Activation of dodecanedioic acid

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. Production of Sebacoylcarnitine

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. Production of Suberylcarnitine

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 3 moreperoxisome, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 6 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 6 moreperoxisome, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 6 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 5 moreperoxisome, cytosolOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 6 moreperoxisome, cytosol

• hexadecanedioyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 6 moreperoxisome, cytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. fatty-acid-CoA ligase

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 4 moreperoxisome, cytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by ACOX3, ACOX1, MOGAT1peroxisome, cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACOX3, ACOX1, LPCAT2, LPCAT1peroxisome, cytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOX3, ACOX1, LPCAT4peroxisome, cytosol

• 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Beta Oxidation Fatty Acid
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOX3, ACOX1, ACADM, ACADS and 1 moreperoxisome, mitochondrial matrix

• 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOX3, ACOX1, SCD, SCD5 and 1 moreperoxisome

• 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACOX3, ACOX1, SCD, SCD5 and 1 moreperoxisome

• 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACOX3, ACOX1, SCD, SCD5 and 1 moreperoxisome

• undecanoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 9 moreperoxisome, cytosolOne of 3 routes

• hexadecanoateReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)

  Catalysed by ACOX3, ACOX1, SCD, SCD5 and 17 moreperoxisome

• N-hexadecanoylhexadecasphinganineReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. hexadecasphinganine + hexadecanoyl-CoA = N-hexadecanoylhexadecasphinganine + CoA + H(+)

  Catalysed by ACOX3, ACOX1, SCD, SCD5 and 2 moreperoxisome

• 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by ACOX3, ACOX1, SCD, SCD5 and 1 moreperoxisome

• (5Z)-tetradecenoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 9 routes

• (3E)-decenoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 7 moreperoxisome, cytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 6 moreperoxisome, cytosol, mitochondrial matrix

• an N(2)-acyl-L-glutamineReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ACOX3, ACOX1, GLYATL1B, GLYATL1peroxisome, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. Palmitoleoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACOX3, ACOX1, ACOT7, BAAT and 11 moreperoxisome, cytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by ACOX3, ACOX1, ACAA1, SCP2 and 2 moreperoxisome, cytosol