O-dodecanoyl-R-carnitine

Three steps

• a triacyl-sn-glycerolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, DGAT1 and 5 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, LCLAT1 and 2 morecytosol

• hexacosanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 11 routes

• docosanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 10 routes

• N-(tetradecanoyl)-sphinganineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CERS6 and 1 morecytosol

• 3-oxohexadecasphinganineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, SPTLC1 and 1 morecytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 9 routes

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, GPAT3 and 3 morecytosol

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ABHD12cytosol, endoplasmic reticulum

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, ABHD16Acytosol, endoplasmic reticulum

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, AGPAT2cytosol

• N-dodecanoylsphing-4-enineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 7 morecytosol

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 10 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 7 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 10 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 7 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 8 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 6 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 5 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 7 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 5 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 8 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 6 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 8 routes

• heptadecanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 7 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 6 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 6 routes

• 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, AGPAT2 and 4 morecytosol

• nonadecanoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 7 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosolOne of 3 routes

• (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX12Bcytosol, endoplasmic reticulum

• 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Fatty Acid Beta Oxidation (C12->C10), Mitochondrial
  3. decanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, ACADM and 4 morecytosol, mitochondrial matrix

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, LPCAT1cytosol

• (8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. Arachidonate:oxygen 8-oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, ALOX12cytosol, endoplasmic reticulumOne of 2 routes

• a 2,3-diacyl-sn-glycerolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, MOGAT2 and 1 morecytosol

• 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. fatty-acyl-CoA synthase (N-C14:0CoA)
  3. 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, MOGAT2 and 1 morecytosol

• 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. fatty acid amide hydrolase (arachidonate)

  Catalysed by CPT1A, CPT1C, CPT1B, FAAHcytosol, endoplasmic reticulum

• 1-O-alkyl-3-acylglycerolReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. acyl-CoA pool formation and breakdown
  3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA

  Catalysed by CPT1A, CPT1C, CPT1B, MOGAT2 and 1 morecytosol

• dodecanedioyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Activation of dodecanedioic acid

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Production of Sebacoylcarnitine

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Production of Suberylcarnitine

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosolOne of 4 routes

• hexanedioyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 6 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 3 morecytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Lauroyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACOT7 and 11 morecytosolOne of 6 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. arachidonic acid:oxygen 1-oxidoreductase

  Catalysed by CPT1A, CPT1C, CPT1B, CYP1A1 and 26 morecytosol, endoplasmic reticulumOne of 3 routes

• 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoateReach from here →
  1. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by CPT1A, CPT1C, CPT1B, CYP2C9cytosol, endoplasmic reticulum