(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

187 compounds within 3 steps: 1 in 1, 7 in 2, 179 in 3

Three steps

a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by TECRL, TECR, FADS1, MBOAT7 and 1 morecytosol
1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-O-octadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by TECRL, TECR, FADS1, LPCAT2cytosol
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by TECRL, TECR, FADS1, LPCAT4cytosol
a 2,3-diacyl-sn-glycerolReach from here →
1. very-long-chain enoyl-CoA reductase
2. acyl-CoA pool formation and breakdown
3. a 2-acylglycerol + an acyl-CoA = a 2,3-diacyl-sn-glycerol + CoA
Catalysed by TECRL, TECR, MOGAT2, MOGAT1cytosol
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 2-(9Z-octadecenoyl)-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by TECRL, TECR, FADS1, MOGAT2 and 1 morecytosol
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by TECRL, TECR, FADS1, LCLAT1cytosol
1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by TECRL, TECR, FADS1, LCLAT1cytosol
1-O-alkyl-3-acylglycerolReach from here →
1. very-long-chain enoyl-CoA reductase
2. acyl-CoA pool formation and breakdown
3. 1-O-alkylglycerol + an acyl-CoA = 1-O-alkyl-3-acylglycerol + CoA
Catalysed by TECRL, TECR, MOGAT2, AWAT2cytosol
dodecanedioyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. Activation of dodecanedioic acid
Catalysed by TECRL, TECR, ACOT7, BAAT and 3 morecytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. Production of Sebacoylcarnitine
Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. Production of Suberylcarnitine
Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by TECRL, TECR, ACOT7, BAAT and 3 morecytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 8 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 6 routes
(R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. Production of 3-Hydroxyoctadecenoylcarnitinec
Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol
(13Z)-eicosenoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)
Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 6 routes
4,8-dimethylnonanoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by TECRL, TECR, ACOT7, BAAT and 5 morecytosol, peroxisomeOne of 3 routes
tetradecanedioyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal
Catalysed by TECRL, TECR, ACOT7, BAAT and 7 morecytosol, peroxisome
hexadecanedioyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. Production of Hexadecanedioylcarnitine
Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosolOne of 2 routes
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by TECRL, TECR, FADS1, AGPAT3cytosol
pristanoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. fatty-acid-CoA ligase
Catalysed by TECRL, TECR, ACOT7, BAAT and 4 morecytosolOne of 2 routes
a 1,3-diacyl-sn-glycerolReach from here →
1. very-long-chain enoyl-CoA reductase
2. acyl-CoA pool formation and breakdown
3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA
Catalysed by TECRL, TECR, MOGAT1cytosolOne of 2 routes
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. very-long-chain enoyl-CoA reductase
2. acyl-CoA pool formation and breakdown
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
Catalysed by TECRL, TECR, LPCAT2, LPCAT1cytosol
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. very-long-chain enoyl-CoA reductase
2. acyl-CoA pool formation and breakdown
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by TECRL, TECR, LPCAT4cytosol
1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-(1Z)-alkenyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by TECRL, TECR, FADS1, LPCAT4 and 1 morecytosol
undecanoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. medium-chain acyl-CoA ligase (undecylic acid)
Catalysed by TECRL, TECR, ACOT7, BAAT and 9 morecytosolOne of 3 routes
1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositolReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-1D-myo-inositol + CoA
Catalysed by TECRL, TECR, FADS1, AGPAT3 and 1 morecytosol
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphateReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-heptadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
Catalysed by TECRL, TECR, FADS1, AGPAT3cytosol
cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
Catalysed by TECRL, TECR, FADS1, SOAT2 and 1 morecytosol
(5Z)-tetradecenoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase (physeteric acid)
Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 9 routes
(3E)-decenoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial
Catalysed by TECRL, TECR, ACOT7, BAAT and 7 morecytosol, mitochondrial matrix
1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
1. very-long-chain enoyl-CoA reductase
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by TECRL, TECR, FADS1, AGPAT3cytosol
(2R,6)-dimethylheptanoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)
Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol, mitochondrial matrix
an N(2)-acyl-L-glutamineReach from here →
1. very-long-chain enoyl-CoA reductase
2. acyl-CoA pool formation and breakdown
3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)
Catalysed by TECRL, TECR, GLYATL1B, GLYATL1cytosol
(7Z)-hexadecenoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 9 routes
tricosanoyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. Dihomo-gamma-linolenoyl-CoA hydrolase
3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 5 routes
a 3-oxoacyl-CoAReach from here →
1. very-long-chain enoyl-CoA reductase
2. acyl-CoA pool formation and breakdown
3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
Catalysed by TECRL, TECR, ACAA1, SCP2 and 2 morecytosol