1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine

Three steps

• 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-octadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)
  2. N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H(+)

  Catalysed by PLA2G4E, PLA2G1B, PLA2G2A, PLA2G5 and 2 more

• 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 11 more

• 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-tetradecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-octadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)
  2. N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)
  3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z)-octadecenoate + H(+)

  Catalysed by PLA2G4E, PLA2G1B, PLA2G2A, PLA2G5 and 2 more

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 2 routes

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by PLAAT3, ENPP2, GDPD3, GDPD1 and 1 more

• 1,2-dihexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + CoA
  3. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phosphate + choline + H(+)

  Catalysed by PLAAT3, PRDX6, LPCAT3, LPCAT1 and 2 moreOne of 3 routes

• 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by PLAAT3, ENPP2, GDPD3, GDPD1 and 2 more

• N-(hexadecanoyl)-sphing-4-enine-1-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
  3. N-hexadecanoylsphing-4-enine + ATP = N-(hexadecanoyl)-sphing-4-enine-1-phosphate + ADP + H(+)

  Catalysed by PLAAT3, NAAA, ASAH1, ACER2 and 2 more

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 2-(9Z-octadecenoyl)-glycerolReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)

  Catalysed by PLAAT3, ABHD11

• 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

  Catalysed by PLAAT3, ENPP2, GDPD3, GDPD1 and 1 more

• 2-hydroxyhexadecanoyl-CoAReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. hexadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyhexadecanoyl-CoA + succinate + CO2

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 2-hydroxyoctadecanoyl-CoAReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• (6Z)-hexadecenoyl-CoAReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. hexadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (6Z)-hexadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• N-acetylcysteamineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)
  3. S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)

  Catalysed by PLAAT3, PPT1, PPT2

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-octadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)
  2. N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)
  3. N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)

  Catalysed by PLA2G4E, PLA2G1B, PLA2G2A, PLA2G5 and 3 moreOne of 2 routes

• 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 15 more

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 10 morecytosol

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
  3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)

  Catalysed by PLAAT3, ABHD11, DGKZ

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 8 morecytosolOne of 2 routes

• 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, TAFAZZIN, LPCAT3, LPCAT1One of 2 routes

• 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by PLAAT3, LPCAT3, MBOAT1, MBOAT2 and 3 moreOne of 3 routes

• 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, TAFAZZIN, LPCAT3

• 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-icosatetraenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, TAFAZZIN, LPCAT3, AGPAT3 and 1 more

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphoserine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-dodecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 10 more

• 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 10 more

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 2 routes

• 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 10 more

• (11Z)-octadecenoyl-CoAReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. stearoyl-CoA desaturase (N-C18:0CoA -> N-C18:1CoA)

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 10 more

• 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerolReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 12 more

• 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerolReach from here →
  1. 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 2-octadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA

  Catalysed by PLAAT3, SLC27A2, ACSL4, ACSL3 and 11 more