N-hexadecanoylsphing-4-enine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

391 compounds within 3 steps: 6 in 1, 63 in 2, 322 in 3

Three steps

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 12 more
1-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G4Cnucleus, cytosolOne of 2 routes
1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 1-tetradecanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 13 more
nonadecanoyl-CoAReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
3. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
Catalysed by NAAA, SLC27A2, ACSL4, ACSL3 and 5 morenucleus, cytosolOne of 6 routes
(11Z)-octadecenoyl-CoAReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
3. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
Catalysed by NAAA, CPT1A, CPT1C, CPT1Bnucleus, cytosolOne of 3 routes
1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1-acyl-2-hexadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 12 more
1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
1. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
Catalysed by GBA1, LCAT, LPCAT2, LPCAT1One of 2 routes
1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 12 more
1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. a 1-acyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 13 more
1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 12 more
1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 1-O-octadecyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 12 more
1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 1-eicosanoyl-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 12 more
1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholineReach from here →
1. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. decanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by GBA1, LCAT, LPCAT1
1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholineReach from here →
1. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. hexanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by GBA1, LCAT, LPCAT1
1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholineReach from here →
1. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. octanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by GBA1, LCAT, LPCAT1
1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
1. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by GBA1, LCAT, LPCAT1
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerolReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 15 more
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerolReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)
Catalysed by NAAA, ABHD11nucleus, cytosol
1-hexadecanoyl-sn-glycerolReach from here →
1. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine
2. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine
3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)
Catalysed by GBA1, LCAT, SMPD2, ENPP6 and 2 more
1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerolReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 14 more
hexadecyl hexadecanoateReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. hexadecan-1-ol + hexadecanoyl-CoA = hexadecyl hexadecanoate + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 14 more
1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 13 more
2-hydroxyhexadecyl hexadecanoateReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 13 more
1,2-O,O-dihexadecanoyl-1,2-hexadecanediolReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 12 more
1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerolReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,3-dihexadecanoyl-2-(9Z-octadecenoyl)glycerol + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 12 more
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 12 more
1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosolOne of 8 routes
2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosolOne of 2 routes
1-octadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosolOne of 5 routes
2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-octadecanoyl-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosol
1-hexadecanoyl-N-(acetyl)-sphing-4-enineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosolOne of 9 routes
2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 2-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosol
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-hexadecanoyl-N-(acetyl)-sphing-4-enine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosolOne of 2 routes
1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosolOne of 3 routes
2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosolOne of 2 routes
2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosol
1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosolOne of 3 routes
1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosol
2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosol
2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosol
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + N-(acetyl)-sphing-4-enine = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine
Catalysed by NAAA, PAFAH2, PLA2G15nucleus, cytosol
hexadecanedioateReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum
3. Fatty Acid Omega Oxidation (W-Ohc16->C16Dc)
Catalysed by NAAA, CYP4F2, CYP4F3, ADH5 and 1 morenucleus, cytosol, endoplasmic reticulum
beta-D-glucosyl-N-dodecanoylsphing-4-enineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine
3. beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by NAAA, ASAH1, ACER2, ASAH2 and 1 morenucleus, cytosolOne of 2 routes
beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
3. beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside
Catalysed by NAAA, ACER2, ACER1, ASAH2 and 1 morenucleus, cytosolOne of 2 routes
dodecanedioyl-CoAReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
3. Activation of dodecanedioic acid
Catalysed by NAAAnucleus, cytosolOne of 4 routes
decanedioyl-CoAReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
3. Production of Sebacoylcarnitine
Catalysed by NAAA, CPT1A, CPT1C, CPT1Bnucleus, cytosolOne of 4 routes
octanedioyl-CoAReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
3. Production of Suberylcarnitine
Catalysed by NAAA, CPT1A, CPT1C, CPT1Bnucleus, cytosolOne of 4 routes
hexanedioyl-CoAReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
3. Activation of adipic acid for Formation of Adipoyl Carnitine
Catalysed by NAAAnucleus, cytosolOne of 4 routes
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)
Catalysed by NAAA, SLC27A2, ACSL4, ACSL3 and 5 morenucleus, cytosolOne of 7 routes
(11Z,14Z)-eicosadienoyl-CoAReach from here →
1. H2O[c] + N-hexadecanoylsphing-4-enine[c] = palmitate[c] + sphingosine[c]
2. Fas180
3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
Catalysed by NAAA, SLC27A2, ACSL4, ACSL3 and 5 morenucleus, cytosolOne of 5 routes