itaconyl-CoA

1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 6 routes

1. Itaconate:CoA ligase (GDP-forming)
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 3 routes

1. Itaconate:CoA ligase (GDP-forming)
2. Activation of dodecanedioic acid

Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrix, cytosolOne of 4 routes

1. Itaconate:CoA ligase (GDP-forming)
2. Production of Sebacoylcarnitine

Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 4 routes

1. Itaconate:CoA ligase (GDP-forming)
2. Production of Suberylcarnitine

Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 4 routes

1. Itaconate:CoA ligase (GDP-forming)
2. Activation of adipic acid for Formation of Adipoyl Carnitine

Catalysed by SUCLG1, SUCLG2, SUCLA2mitochondrial matrix, cytosolOne of 5 routes

1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes

1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

1. Itaconate:CoA ligase (GDP-forming)
2. Production of 3-Hydroxyoctadecenoylcarnitinec

Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosol

1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

1. Itaconate:CoA ligase (GDP-forming)
2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

Catalysed by SUCLG1, SUCLG2, SUCLA2, CRAT and 1 moremitochondrial matrix, peroxisomeOne of 3 routes

1. Itaconate:CoA ligase (GDP-forming)
2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

Catalysed by SUCLG1, SUCLG2, SUCLA2, ACAA1 and 3 moremitochondrial matrix, peroxisome

1. Itaconate:CoA ligase (GDP-forming)
2. Production of Hexadecanedioylcarnitine

Catalysed by SUCLG1, SUCLG2, SUCLA2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 2 routes

1. Itaconate:CoA ligase (GDP-forming)
2. fatty-acid-CoA ligase

Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2mitochondrial matrix, cytosolOne of 2 routes

1. Itaconate:CoA ligase (GDP-forming)
2. medium-chain acyl-CoA ligase (undecylic acid)

Catalysed by SUCLG1, SUCLG2, SUCLA2, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 3 routes

1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (physeteric acid)

Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 8 routes

1. Itaconate:CoA ligase (GDP-forming)
2. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

Catalysed by SUCLG1, SUCLG2, SUCLA2, ACADM and 3 moremitochondrial matrix

1. Itaconate:CoA ligase (GDP-forming)
2. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

Catalysed by SUCLG1, SUCLG2, SUCLA2, HADHA and 2 moremitochondrial matrix

1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 8 routes

1. Itaconate:CoA ligase (GDP-forming)
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

Catalysed by SUCLG1, SUCLG2, SUCLA2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 4 routes

1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
2. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate

Catalysed by SUGCT, OXCT1, OXCT2

1. (3S)-citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)
2. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)

Catalysed by AUH, CLYBL, SLC16A4, SLC16A5 and 4 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

1. Itaconate:CoA ligase (GDP-forming)
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine