serotonin

Three steps

• N-tetradecanoylsphing-4-enineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate

  Catalysed by AANAT, ASAH1, ACER2, ACER1 and 1 morecytosol, Golgi apparatus

• N-hexadecanoylsphing-4-enineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by AANAT, ASAH1, ACER2, ACER1 and 5 morecytosol, Golgi apparatusOne of 2 routes

• N-octadecanoylsphing-4-enineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 8 morecytosolOne of 3 routes

• N-eicosanoyl-sphing-4-enineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 7 morecytosolOne of 2 routes

• N-tetracosanoyl-sphing-4-enineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 8 morecytosol

• a 1-(1-hydroxyalkyl)-sn-glycerolReach from here →
  1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
  3. 1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by DDC, TPH1, TPH2, AGMO

• (9Z,12Z)-octadecadien-1-olReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 7 morecytosol

• (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (DPA)
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + malonyl-CoA + H(+) = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 3-oxooctacosanyol-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctacosanyol-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 7 morecytosol

• 3-oxotetracosanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 12 morecytosolOne of 3 routes

• 3-oxohexacosanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 12 morecytosolOne of 3 routes

• 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 7 morecytosol

• (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 9 morecytosol

• (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (linolenate)
  3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 9 morecytosol

• 3-oxo-(13Z)-docosenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
  3. (11Z)-eicosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-docosenoyl-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 3-oxo-(15Z)-tetracosenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
  3. (13Z)-docosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(15Z)-tetracosenoyl-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 2-hydroxyoctadecanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosol

• N-(15Z-tetracosenoyl)-sphinganineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)
  3. (15Z)-tetracosenoyl-CoA + sphinganine = N-(15Z-tetracosenoyl)-sphinganine + CoA + H(+)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• N-tetracosanoyl-heptadecasphing-4-enineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. heptadecasphing-4-enine + tetracosanoyl-CoA = N-tetracosanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• CHEBI:742324Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1A2, SLCO1B3, COMT, LRTOMTextracellular space, cytosol

• (2E)-hexacosenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. acyl-CoA oxidase (hexacosanoyl-CoA)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, peroxisomeOne of 2 routes

• 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
  3. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• (2S)-2-aminobutanoateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by AANAT, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine

  Catalysed by AANAT, ASAH1, ACER2, ACER1 and 1 morecytosol, Golgi apparatus

• N-(tetracosenoyl)-sphing-4-enineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. tetracosenoyl-CoA + sphing-4-enine = N-(tetracosenoyl)-sphing-4-enine + CoA + H(+)

  Catalysed by AANAT, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus

• 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 9 morecytosolOne of 2 routes

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 10 morecytosol

• 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (margaric acid)
  3. heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 10 morecytosol

• 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 11 morecytosol

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 8 morecytosolOne of 2 routes

• 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 10 morecytosol

• 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
  3. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• (2E)-eicosenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. acyl-CoA oxidase (eicosanoyl-CoA)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, peroxisomeOne of 4 routes

• (2E)-docosenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. acyl-CoA oxidase (docosanoyl-CoA)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, peroxisomeOne of 4 routes

• (2E)-tetracosenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. acyl-CoA oxidase (tetracosanoyl-CoA)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, peroxisomeOne of 3 routes

• 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 7 morecytosol

• 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z)-hexadecenoyl-CoA = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Arachidonate:CoA ligase (AMP-forming)
  3. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 9 morecytosol

• 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 6 morecytosol

• 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosol