hydrogen cyanide

Three steps

• dTMPReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. pyruvate kinase (dTDP)
  3. DTDP Diphosphohydrolase

  Catalysed by MPST, TST, PKM, PKLR and 3 morecytosol, extracellular spaceOne of 5 routes

• 3-demethylubiquinol-10Reach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
  3. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)

  Catalysed by MPST, TST, SQOR, COQ3mitochondrial matrix

• Mo-molybdopterinReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by MPST, TST, AGXT2, MOCOScytosol, mitochondrial matrix

• (2S)-2-aminobutanoateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrixOne of 6 routes

• 2-iminobutanoateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)

  Catalysed by MPST, TST, AGXT2, RIDAcytosol

• 2-aminoprop-2-enoateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. D-serine = pyruvate + NH4(+)
  3. D-serine = 2-aminoprop-2-enoate + H2O

  Catalysed by MPST, TST, SRRcytosol

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GPX1 and 1 moremitochondrial matrix

• glycodeoxycholateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by MPST, TST, TSTD1, ABCC4mitochondrial matrix, inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GPX1 and 2 moremitochondrial matrix

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, PTGES and 5 moremitochondrial matrix

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GPX1 and 1 moremitochondrial matrix

• thromboxane B2Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. thromboxane B2(out) + 2 (S)-lactate(in) = thromboxane B2(in) + 2 (S)-lactate(out)

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by MPST, TST, TSTD1, GSTT4 and 22 moremitochondrial matrixOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GPX1 and 3 moremitochondrial matrix

• taurochenodeoxycholateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by MPST, TST, TSTD1, ABCC4mitochondrial matrix, inner side of the membrane, outer side of the membrane

• thiamine(1+) diphosphateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
  3. 2-(alpha-hydroxyethyl)thiamine-diphosphate[m] + lipoamide[m] = S-acetyldihydrolipoamide[m] + thiamin-PP[m]

  Catalysed by MPST, TST, PDHA1, PDHB and 2 morecytosol, mitochondrial matrix