enol-phenylpyruvate

Three steps

• oxalateReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)

  Catalysed by MIF, AADAT, HAO1

• glutarateReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O
  3. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)

  Catalysed by MIF, AADAT, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by MIF, AADAT

• L-ornithineReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of ornithine and phenylalanine (cytosol to extracellular)

  Catalysed by MIF, GOT2, TAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• glycineReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by MIF, GOT2, TAT, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 22 routes

• 2-oxoadipateReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by MIF, AADAT

• L-dopaReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by MIF, GOT2, TAT, SLC7A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-histidineReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

  Catalysed by MIF, GOT2, TAT, SLC7A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-methionineReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of methionine and phenylalanine (cytosol to extracellular)

  Catalysed by MIF, GOT2, TAT, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• L-tryptophanReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of phenylalanine and tryptophan (cytosol to extracellular)

  Catalysed by MIF, GOT2, TAT, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• L-kynurenineReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. Transport of L-Kynurenine

  Catalysed by MIF, GOT2, TAT, SLC7A8mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• L-alanineReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of alanine and phenylalanine (cytosol to extracellular)

  Catalysed by MIF, GOT2, TAT, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• L-asparagineReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. transport of asparagine and phenylalanine (cytosol to extracellular)

  Catalysed by MIF, GOT2, TAT, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 3 routes

• L-tyrosineReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. Phenylalanine Transaminase, Mitochondrial
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by MIF, GOT2, TAT, PAHmitochondrial matrix

• 5-amino-2-oxopentanoateReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine

  Catalysed by MIF, AADAT, AGXT2

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by MIF, AADAT, HOGA1

• xanthurenateReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. 3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

  Catalysed by MIF, AADAT, KYAT3

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by MIF, AADAT, HOGA1

• 3-methylmalateReach from here →
  1. 3-phenylpyruvate = enol-phenylpyruvate
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by MIF, AADAT, CLYBL