Proteins/UNIPROT:O43593

HR

ProteinUNIPROT:O43593Lysine-specific demethylase hairless

Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle..

Function from UniProtKB (O43593), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

alopecia universalis congenita has a germline basis in HRDiseaseGenCC HGNC:5172|MONDO:0008757Inferred only
atrichia with papular lesions has a germline basis in HRDiseaseGenCC HGNC:5172|MONDO:0008847Inferred only
hypotrichosis 4 has a germline basis in HRDiseaseGenCC HGNC:5172|MONDO:0100522Inferred only
Marie Unna hereditary hypotrichosis has a germline basis in HRDiseaseGenCC HGNC:5172|MONDO:0018631Inferred only

Statements

17 statements

17 statements · 5 reference databases · Subject: HR · Sources: Bgee, gene ontology, Hetionet, UniProt, WikiPathways

Order

NPDC1 covaries with HRProteinHetionet hetionet:covaries:55806-56654Inferred only
HR is expressed in skin of legAnatomyBgee ENSG00000168453Inferred only
HR is expressed in zone of skinAnatomyBgee ENSG00000168453Inferred only
HDAC1 interacts with HRProteinHetionet hetionet:interacts:3065-55806Inferred only
HDAC2 interacts with HRProteinHetionet hetionet:interacts:3066-55806Inferred only
HDAC3 interacts with HRProteinHetionet hetionet:interacts:55806-8841Inferred only
HDAC5 interacts with HRProteinHetionet hetionet:interacts:10014-55806Inferred only
HMGB1 interacts with HRProteinHetionet hetionet:interacts:3146-55806Inferred only
RARA interacts with HRProteinHetionet hetionet:interacts:55806-5914Inferred only
RARB interacts with HRProteinHetionet hetionet:interacts:55806-5915Inferred only
TBL1X interacts with HRProteinHetionet hetionet:interacts:55806-6907Inferred only
THRA interacts with HRProteinHetionet hetionet:interacts:55806-7067Inferred only

Show the remaining 5

TRIM27 interacts with HRProteinHetionet hetionet:interacts:55806-5987Inferred only
VDR interacts with HRProteinHetionet hetionet:interacts:55806-7421Inferred only
HR participates in Hair follicle development cytodifferentiation stage 3 of 3PathwayWikiPathways WP2840Inferred only
HR regulates regulation of transcription by RNA polymerase IIBiological processgene ontology O43593|GO:0006357Inferred only
HR requires the cofactor iron(2+)CompoundUniProt O43593Inferred only

Reactions

1 reaction

N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3]+22-oxoglutarate(2-)+2dioxygenL-lysyl(9)-[histone H3]+2formaldehyde+2succinate(2-)+2carbon dioxide
Catalysed by HR or KDM1A or KDM7A or KDM3B or PHF8 or KDM3A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60188CC BY 4.0Reference data

Other names

1 name

Resolves to: HR

Also called: [histone H3]-dimethyl-L-lysine(9) demethylase hairless

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