Proteins/UNIPROT:Q9UNZ2

NSFL1C

ProteinUNIPROT:Q9UNZ2

Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis..

Function from UniProtKB (Q9UNZ2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

67 statements

67 statements · 4 reference databases · Subject: NSFL1C · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

NSFL1C covaries with ATP6V0BProteinHetionet hetionet:covaries:533-55968Inferred only
ZFP36L1 covaries with NSFL1CProteinHetionet hetionet:covaries:55968-677Inferred only
ANP32A interacts with NSFL1CProteinHetionet hetionet:interacts:55968-8125Inferred only
CDK1 interacts with NSFL1CProteinHetionet hetionet:interacts:55968-983Inferred only
CDV3 interacts with NSFL1CProteinHetionet hetionet:interacts:55573-55968Inferred only
DBI interacts with NSFL1CProteinHetionet hetionet:interacts:1622-55968Inferred only
FAM32A interacts with NSFL1CProteinHetionet hetionet:interacts:26017-55968Inferred only
GLMN interacts with NSFL1CProteinHetionet hetionet:interacts:11146-55968Inferred only
GSK3B interacts with NSFL1CProteinHetionet hetionet:interacts:2932-55968Inferred only
LIPE interacts with NSFL1CProteinHetionet hetionet:interacts:3991-55968Inferred only
NGLY1 interacts with NSFL1CProteinHetionet hetionet:interacts:55768-55968Inferred only
PHAX interacts with NSFL1CProteinHetionet hetionet:interacts:51808-55968Inferred only

Show the remaining 55

PSMD2 interacts with NSFL1CProteinHetionet hetionet:interacts:55968-5708Inferred only
RPL22 interacts with NSFL1CProteinHetionet hetionet:interacts:55968-6146Inferred only
SRP14 interacts with NSFL1CProteinHetionet hetionet:interacts:55968-6727Inferred only
STX5 interacts with NSFL1CProteinHetionet hetionet:interacts:55968-6811Inferred only
TARDBP interacts with NSFL1CProteinHetionet hetionet:interacts:23435-55968Inferred only
UBC interacts with NSFL1CProteinHetionet hetionet:interacts:55968-7316Inferred only
VCP interacts with NSFL1CProteinHetionet hetionet:interacts:55968-7415Inferred only
NSFL1C participates in Alstrom syndromePathwayWikiPathways WP5202Inferred only
NSFL1C participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
NSFL1C participates in RHOH GTPase cyclePathwayReactome R-HSA-9013407Inferred only
NSFL1C participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
NSFL1C participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
NSFL1C participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
NSFL1C regulates negative regulation of protein localization to centrosomeBiological processgene ontology Q9UNZ2|GO:1904780Inferred only
NSFL1C regulates positive regulation of mitotic centrosome separationBiological processgene ontology Q9UNZ2|GO:0046604Inferred only
NSFL1C decreases the expression of ABL1ProteinHetionet hetionet:regulates:55968-25Inferred only
NSFL1C decreases the expression of ANXA4ProteinHetionet hetionet:regulates:55968-307Inferred only
NSFL1C decreases the expression of ARHGAP1ProteinHetionet hetionet:regulates:55968-392Inferred only
NSFL1C increases the expression of B4GAT1ProteinHetionet hetionet:regulates:55968-11041Inferred only
NSFL1C decreases the expression of CANT1ProteinHetionet hetionet:regulates:55968-124583Inferred only
NSFL1C decreases the expression of CCDC86ProteinHetionet hetionet:regulates:55968-79080Inferred only
NSFL1C decreases the expression of CDC25BProteinHetionet hetionet:regulates:55968-994Inferred only
NSFL1C decreases the expression of CDKN1BProteinHetionet hetionet:regulates:55968-1027Inferred only
NSFL1C increases the expression of CLPXProteinHetionet hetionet:regulates:55968-10845Inferred only
NSFL1C decreases the expression of CNDP2ProteinHetionet hetionet:regulates:55968-55748Inferred only
NSFL1C decreases the expression of COG2ProteinHetionet hetionet:regulates:55968-22796Inferred only
NSFL1C increases the expression of COL11A1ProteinHetionet hetionet:regulates:55968-1301Inferred only
NSFL1C increases the expression of CSGALNACT1ProteinHetionet hetionet:regulates:55968-55790Inferred only
NSFL1C decreases the expression of DNAJA3ProteinHetionet hetionet:regulates:55968-9093Inferred only
NSFL1C decreases the expression of H2BC12ProteinHetionet hetionet:regulates:55968-85236Inferred only
NSFL1C increases the expression of IKBKBProteinHetionet hetionet:regulates:55968-3551Inferred only
NSFL1C decreases the expression of JPT2ProteinHetionet hetionet:regulates:55968-90861Inferred only
NSFL1C decreases the expression of KIF20AProteinHetionet hetionet:regulates:55968-10112Inferred only
NSFL1C increases the expression of LBRProteinHetionet hetionet:regulates:55968-3930Inferred only
NSFL1C increases the expression of LGMNProteinHetionet hetionet:regulates:55968-5641Inferred only
NSFL1C decreases the expression of NT5DC2ProteinHetionet hetionet:regulates:55968-64943Inferred only
NSFL1C decreases the expression of OXA1LProteinHetionet hetionet:regulates:55968-5018Inferred only
NSFL1C decreases the expression of PAK4ProteinHetionet hetionet:regulates:55968-10298Inferred only
NSFL1C increases the expression of PLK1ProteinHetionet hetionet:regulates:55968-5347Inferred only
NSFL1C decreases the expression of PPP2R5EProteinHetionet hetionet:regulates:55968-5529Inferred only
NSFL1C decreases the expression of PTK2ProteinHetionet hetionet:regulates:55968-5747Inferred only
NSFL1C decreases the expression of PTPRKProteinHetionet hetionet:regulates:55968-5796Inferred only
NSFL1C decreases the expression of RAI14ProteinHetionet hetionet:regulates:55968-26064Inferred only
NSFL1C decreases the expression of RPIAProteinHetionet hetionet:regulates:55968-22934Inferred only
NSFL1C decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:55968-6192Inferred only
NSFL1C increases the expression of SERPINA3ProteinHetionet hetionet:regulates:55968-12Inferred only
NSFL1C decreases the expression of TARBP1ProteinHetionet hetionet:regulates:55968-6894Inferred only
NSFL1C decreases the expression of TCEA2ProteinHetionet hetionet:regulates:55968-6919Inferred only
NSFL1C decreases the expression of THAP11ProteinHetionet hetionet:regulates:55968-57215Inferred only
NSFL1C decreases the expression of TIMP1ProteinHetionet hetionet:regulates:55968-7076Inferred only
NSFL1C increases the expression of TMEM109ProteinHetionet hetionet:regulates:55968-79073Inferred only
NSFL1C decreases the expression of TUBA1AProteinHetionet hetionet:regulates:55968-7846Inferred only
NSFL1C decreases the expression of UGDHProteinHetionet hetionet:regulates:55968-7358Inferred only
NSFL1C decreases the expression of VPS28ProteinHetionet hetionet:regulates:55968-51160Inferred only
NSFL1C increases the expression of WIF1ProteinHetionet hetionet:regulates:55968-11197Inferred only

Other names

3 names

Resolves to: NSFL1C

Also called: p97 cofactor p47UBX domain-containing protein 2CUBXN2C

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