Proteins/UNIPROT:Q96KP6

TNIP3

ProteinUNIPROT:Q96KP6

Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding..

Function from UniProtKB (Q96KP6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 4 reference databases · Subject: TNIP3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

TNIP3 covaries with HNRNPH2ProteinHetionet hetionet:covaries:3188-79931Inferred only
TNIP3 covaries with QRFPRProteinHetionet hetionet:covaries:79931-84109Inferred only
TNIP3 covaries with TARBP1ProteinHetionet hetionet:covaries:6894-79931Inferred only
TNIP3 covaries with ZNF26ProteinHetionet hetionet:covaries:7574-79931Inferred only
TNIP3 covaries with ZNF461ProteinHetionet hetionet:covaries:79931-92283Inferred only
TNIP3 covaries with ZNF865ProteinHetionet hetionet:covaries:100507290-79931Inferred only
TNFAIP3 interacts with TNIP3ProteinHetionet hetionet:interacts:7128-79931Inferred only
UBC interacts with TNIP3ProteinHetionet hetionet:interacts:7316-79931Inferred only
TNIP3 participates in DeubiquitinationPathwayReactome R-HSA-5688426Inferred only
TNIP3 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
TNIP3 participates in Ovarian tumor domain proteasesPathwayReactome R-HSA-5689896Inferred only
TNIP3 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Show the remaining 3

TNIP3 participates in RAC1 PAK1 p38 MMP2 pathwayPathwayWikiPathways WP3303Inferred only
TNIP3 regulates negative regulation of canonical NF-kappaB signal transductionBiological processgene ontology Q96KP6|GO:0043124Inferred only
TNIP3 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q96KP6|GO:0006357Inferred only

Other names

5 names

Resolves to: TNIP3

Also called: A20-binding inhibitor of NF-kappa-B activation 3ABIN-3ABIN3LINDListeria-induced gene protein

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