Loading the page.
Proteins/UNIPROT:Q9NR22
S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer. Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS..
Function from UniProtKB (Q9NR22), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
48 statements
48 statements · 4 reference databases · Subject: PRMT8 · Sources: gene ontology, Hetionet, Human Protein Atlas, WikiPathways
2 reactions
L-arginyl-[protein]+2S-adenosyl-L-methionineN(omega),N(omega)-dimethyl-L-arginyl-[protein]+2S-adenosyl-L-homocysteine+2hydron
Catalysed by PRMT3 or PRMT2 or CARM1 or METTL23 or PRMT6 or PRMT1 or PRMT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48096CC BY 4.0Reference data
L-arginyl-[protein]+
3 names
Resolves to: PRMT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48100CC BY 4.0Reference data