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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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PathwaysReactions grouped under one name
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Reference

Evidence

Compounds
Outcomes
Proteins
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Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:A2PYH4

HFM1

Protein·UNIPROT:A2PYH4

Open in the graph

Required for crossover formation and complete synapsis of homologous chromosomes during meiosis..

Function from UniProtKB (A2PYH4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

premature ovarian failure 9 has a germline basis in HFM1DiseaseGenCC HGNC:20193|MONDO:0014322Inferred only

Statements

3 statements

3 statements · 3 reference databases · Subject: HFM1 · Sources: Hetionet, UniProt, WikiPathways

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MRPS31 covaries with HFM1ProteinHetionet hetionet:covaries:10240-164045Inferred only
HFM1 participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
HFM1 requires the cofactor Zn(2+)CompoundUniProt A2PYH4Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

3 names

Resolves to: HFM1

Also called: DNA 3'-5' helicase HFM1SEC3D1SEC63 domain-containing protein 1

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Balanced

Rhea RHEA:13065CC BY 4.0Reference data