Proteins/UNIPROT:Q9Y2E5

MAN2B2

ProteinUNIPROT:Q9Y2E5

Specifically cleaves terminal alpha 1,6-linked mannose residues on Man3GlcNAc and Man2GlcNAc core oligosaccharides generated by N-glycan degradation pathways, having little activity, if any, on larger mannose oligosaccharides. Does not cleave terminal alpha 1,6-linked mannose on Man3GlcNAc2, and is also unable to hydrolyze terminal alpha 1,3-mannose linkages..

Function from UniProtKB (Q9Y2E5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

congenital disorder of glycosylation has a germline basis in MAN2B2DiseaseGenCC HGNC:29623|MONDO:0015286Inferred only

Statements

25 statements

25 statements · 4 reference databases · Subject: MAN2B2 · Sources: Hetionet, Reactome, Rhea, UniProt

Order

MAN2B2 covaries with CD247ProteinHetionet hetionet:covaries:23324-919Inferred only
LMOD1 covaries with MAN2B2ProteinHetionet hetionet:covaries:23324-25802Inferred only
MAN2B2 covaries with LUZP2ProteinHetionet hetionet:covaries:23324-338645Inferred only
PITRM1 covaries with MAN2B2ProteinHetionet hetionet:covaries:10531-23324Inferred only
MAN2B2 covaries with PPP1R12BProteinHetionet hetionet:covaries:23324-4660Inferred only
MAN2B2 covaries with RPS6KA5ProteinHetionet hetionet:covaries:23324-9252Inferred only
SLC6A18 covaries with MAN2B2ProteinHetionet hetionet:covaries:23324-348932Inferred only
UBC interacts with MAN2B2ProteinHetionet hetionet:interacts:23324-7316Inferred only
MAN2B2 participates in Lysosomal oligosaccharide catabolismPathwayReactome R-HSA-8853383Inferred only
MAN2B2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
MAN2B2 participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
DHPS increases the expression of MAN2B2ProteinHetionet hetionet:regulates:1725-23324Inferred only

Show the remaining 13

LRPAP1 decreases the expression of MAN2B2ProteinHetionet hetionet:regulates:4043-23324Inferred only
MYCBP increases the expression of MAN2B2ProteinHetionet hetionet:regulates:26292-23324Inferred only
PAX8 increases the expression of MAN2B2ProteinHetionet hetionet:regulates:7849-23324Inferred only
PKN1 increases the expression of MAN2B2ProteinHetionet hetionet:regulates:5585-23324Inferred only
RUFY1 decreases the expression of MAN2B2ProteinHetionet hetionet:regulates:80230-23324Inferred only
STAT3 decreases the expression of MAN2B2ProteinHetionet hetionet:regulates:6774-23324Inferred only
SUCLG2 increases the expression of MAN2B2ProteinHetionet hetionet:regulates:8801-23324Inferred only
VAT1 increases the expression of MAN2B2ProteinHetionet hetionet:regulates:10493-23324Inferred only
ZNF398 increases the expression of MAN2B2ProteinHetionet hetionet:regulates:57541-23324Inferred only
ZNF546 decreases the expression of MAN2B2ProteinHetionet hetionet:regulates:339327-23324Inferred only
MAN2B2 requires the cofactor Co(2+)CompoundUniProt Q9Y2E5Inferred only
MAN2B2 requires the cofactor Zn(2+)CompoundUniProt Q9Y2E5Inferred only
alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc is a substrate of MAN2B2CompoundRhea RHEA:84971Inferred only

Reactions

3 reactions

MAM00141l+2waterMAM01382l+2D-mannose
Catalysed by MAN2B2 or MAN2B1 or MAN2C1
Reaction pageLeft to rightBalancedEC 3.2.1.24lysosome
Human-GEM MAR07428CC BY 4.0Reference data
alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc+waterCHEBI:151271+D-mannose
Catalysed by MAN2B2
Reaction page

Other names

5 names

Resolves to: MAN2B2

Also called: Alpha-1,6-mannosidaseCore-specific lysosomal alpha-1,6-MannosidaseEpmanKIAA0935Mannosidase alpha class 2B member 2

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