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Proteins/UNIPROT:P52429
Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle. Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently..
Function from UniProtKB (P52429), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
28 statements
28 statements · 5 reference databases · Subject: DGKE · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
9 reactions
4 names
Resolves to: DGKE
a 1,2-diacyl-sn-glycerol+ATP(4-)a 1,2-diacyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:10272CC BY 4.0Reference data
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol+ATP(4-)1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40323CC BY 4.0Reference data
1,2-di-(9Z-octadecenoyl)-sn-glycerol+ATP(4-)1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKA or DGKG or DGKE or DGKQ or DGKZ or DGKD or AGK or DGKK or DGKH or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40327CC BY 4.0Reference data
CHEBI:87223+ATP(4-)CHEBI:77094+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40331CC BY 4.0Reference data
CHEBI:77096+ATP(4-)1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40335CC BY 4.0Reference data
1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol+ATP(4-)1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKI or DGKG or DGKE or DGKB
Reaction pageLeft to rightBalanced
Rhea RHEA:40339CC BY 4.0Reference data
CHEBI:77125+ATP(4-)1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:40351CC BY 4.0Reference data
CHEBI:77127+ATP(4-)1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate+ADP(3-)+hydron
Catalysed by DGKE
Reaction pageLeft to rightBalanced
Rhea RHEA:40355CC BY 4.0Reference data