Proteins/UNIPROT:Q4KMQ1

TPRN

ProteinUNIPROT:Q4KMQ1

Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity. Recruited to sites of DNA damage and may play a role in DNA damage repair..

Function from UniProtKB (Q4KMQ1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

autosomal recessive nonsyndromic hearing loss 79 has a germline basis in TPRNDiseaseGenCC HGNC:26894|MONDO:0013215Inferred only
hearing loss, autosomal recessive has a germline basis in TPRNDiseaseGenCC HGNC:26894|MONDO:0019588Inferred only
nonsyndromic genetic hearing loss has a germline basis in TPRNDiseaseGenCC HGNC:26894|MONDO:0019497Inferred only

Statements

10 statements

10 statements · 2 reference databases · Subject: TPRN · Sources: Hetionet, Reactome

Order

TPRN covaries with CACNA1HProteinHetionet hetionet:covaries:286262-8912Inferred only
TMPRSS7 covaries with TPRNProteinHetionet hetionet:covaries:286262-344805Inferred only
CLIC1 interacts with TPRNProteinHetionet hetionet:interacts:1192-286262Inferred only
EPS8 interacts with TPRNProteinHetionet hetionet:interacts:2059-286262Inferred only
PPP1CA interacts with TPRNProteinHetionet hetionet:interacts:286262-5499Inferred only
PPP1CC interacts with TPRNProteinHetionet hetionet:interacts:286262-5501Inferred only
TPRN participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
TPRN participates in Sensory processing of soundPathwayReactome R-HSA-9659379Inferred only
TPRN participates in Sensory processing of sound by inner hair cells of the cochleaPathwayReactome R-HSA-9662360Inferred only
TPRN participates in Sensory processing of sound by outer hair cells of the cochleaPathwayReactome R-HSA-9662361Inferred only

Other names

2 names

Resolves to: TPRN

Also called: C9orf75Taperin

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