Proteins/UNIPROT:P55061

TMBIM6

ProteinUNIPROT:P55061

Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity)..

Function from UniProtKB (P55061), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 2 reference databases · Subject: TMBIM6 · Sources: gene ontology, Hetionet

Order

BAD interacts with TMBIM6ProteinHetionet hetionet:interacts:572-7009Inferred only
BCL2 interacts with TMBIM6ProteinHetionet hetionet:interacts:596-7009Inferred only
CEBPD interacts with TMBIM6ProteinHetionet hetionet:interacts:1052-7009Inferred only
TMBIM6 interacts with CERS2ProteinHetionet hetionet:interacts:29956-7009Inferred only
TMBIM6 interacts with TRAF6ProteinHetionet hetionet:interacts:7009-7189Inferred only
TMBIM6 interacts with UBCProteinHetionet hetionet:interacts:7009-7316Inferred only
TMBIM6 interacts with VTI1AProteinHetionet hetionet:interacts:143187-7009Inferred only
TMBIM6 regulates negative regulation of apoptotic processBiological processgene ontology P55061|GO:0043066Inferred only
TMBIM6 regulates negative regulation of apoptotic signaling pathwayBiological processgene ontology P55061|GO:2001234Inferred only
TMBIM6 regulates negative regulation of calcium ion transport into cytosolBiological processgene ontology P55061|GO:0010523Inferred only
TMBIM6 regulates negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayBiological processgene ontology P55061|GO:1902236Inferred only
TMBIM6 regulates negative regulation of hypoxia-induced intrinsic apoptotic signaling pathwayBiological processgene ontology P55061|GO:1903298Inferred only

Show the remaining 7

TMBIM6 regulates negative regulation of immunoglobulin productionBiological processgene ontology P55061|GO:0002638Inferred only
TMBIM6 regulates negative regulation of IRE1-mediated unfolded protein responseBiological processgene ontology P55061|GO:1903895Inferred only
TMBIM6 regulates negative regulation of RNA splicingBiological processgene ontology P55061|GO:0033119Inferred only
TMBIM6 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology P55061|GO:0000122Inferred only
AKAP9 decreases the expression of TMBIM6ProteinHetionet hetionet:regulates:10142-7009Inferred only
CSNK1E decreases the expression of TMBIM6ProteinHetionet hetionet:regulates:1454-7009Inferred only
PIK3C2A increases the expression of TMBIM6ProteinHetionet hetionet:regulates:5286-7009Inferred only

Other names

5 names

Resolves to: TMBIM6

Also called: BI-1BI1TEGTTestis-enhanced gene transcript proteinTransmembrane BAX inhibitor motif-containing protein 6

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