Proteins/UNIPROT:Q9NY26

SLC39A1

ProteinUNIPROT:Q9NY261 compound

Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space. Functions as the major importer of zinc from circulating blood plasma into prostate cells..

Function from UniProtKB (Q9NY26), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · transported by

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

Zn(2+)ElementCHEBI:29105Inferred only4 paths2 endpoints

What the reference databases state

Statements

26 statements

26 statements · 5 reference databases · Subject: SLC39A1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

Order

CUTA covaries with SLC39A1ProteinHetionet hetionet:covaries:27173-51596Inferred only
LMNA covaries with SLC39A1ProteinHetionet hetionet:covaries:27173-4000Inferred only
LPAR4 covaries with SLC39A1ProteinHetionet hetionet:covaries:27173-2846Inferred only
SLC39A1 interacts with CERS2ProteinHetionet hetionet:interacts:27173-29956Inferred only
KCNAB1 interacts with SLC39A1ProteinHetionet hetionet:interacts:27173-7881Inferred only
KCNAB2 interacts with SLC39A1ProteinHetionet hetionet:interacts:27173-8514Inferred only
PLEKHM2 interacts with SLC39A1ProteinHetionet hetionet:interacts:23207-27173Inferred only
PRKCZ interacts with SLC39A1ProteinHetionet hetionet:interacts:27173-5590Inferred only
SHB interacts with SLC39A1ProteinHetionet hetionet:interacts:27173-6461Inferred only
SLC39A1 interacts with SLC39A2ProteinHetionet hetionet:interacts:27173-29986Inferred only
UBC interacts with SLC39A1ProteinHetionet hetionet:interacts:27173-7316Inferred only
SLC39A1 participates in Metal ion SLC transportersPathwayReactome R-HSA-425410Inferred only

Show the remaining 14

SLC39A1 participates in NRF2 pathwayPathwayWikiPathways WP2884Inferred only
SLC39A1 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
SLC39A1 participates in Senescence and autophagy in cancerPathwayWikiPathways WP615Inferred only
SLC39A1 participates in SLC-mediated transmembrane transportPathwayReactome R-HSA-425407Inferred only
SLC39A1 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
SLC39A1 participates in Zinc homeostasisPathwayWikiPathways WP3529Inferred only
SLC39A1 participates in Zinc influx into cells by the SLC39 gene familyPathwayReactome R-HSA-442380Inferred only
SLC39A1 participates in Zinc transportersPathwayReactome R-HSA-435354Inferred only
CASP3 decreases the expression of SLC39A1ProteinHetionet hetionet:regulates:836-27173Inferred only
IKBKG decreases the expression of SLC39A1ProteinHetionet hetionet:regulates:8517-27173Inferred only
RAB4A decreases the expression of SLC39A1ProteinHetionet hetionet:regulates:5867-27173Inferred only
proton is transported by SLC39A1CompoundHuman-GEM MAR05989Inferred only
Zn(2+) is transported by SLC39A1CompoundRhea RHEA:29351Inferred only
Zn(2+) is transported by SLC39A1CompoundHuman-GEM MAR05989Inferred only

Reactions

2 reactions

proton+Zn(2+)proton+Zn(2+)
Transported by SLC39A14 or SLC11A2 or SLC39A8 or SLC39A5 or SLC39A6 or SLC39A3 or SLC39A1 or SLC39A4 or SLC39A2 or SLC39A10
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05989CC BY 4.0Reference data

Other names

8 names

Resolves to: SLC39A1

Also called: hZIP1IRT1Solute carrier family 39 member 1Zinc-iron-regulated transporter-likeZIP-1ZIP1ZIRTLZrt- and Irt-like protein 1

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