Proteins/UNIPROT:P62166

NCS1

ProteinUNIPROT:P62166

Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity)..

Function from UniProtKB (P62166), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

48 statements

48 statements · 2 reference databases · Subject: NCS1 · Sources: gene ontology, Hetionet

Order

NCS1 covaries with ACTA1ProteinHetionet hetionet:covaries:23413-58Inferred only
NCS1 covaries with ACTG1ProteinHetionet hetionet:covaries:23413-71Inferred only
NCS1 covaries with ATOH7ProteinHetionet hetionet:covaries:220202-23413Inferred only
NCS1 covaries with ATP6V0D1ProteinHetionet hetionet:covaries:23413-9114Inferred only
NCS1 covaries with ATP6V1G2ProteinHetionet hetionet:covaries:23413-534Inferred only
NCS1 covaries with C1QL3ProteinHetionet hetionet:covaries:23413-389941Inferred only
NCS1 covaries with CAMK2DProteinHetionet hetionet:covaries:23413-817Inferred only
NCS1 covaries with CDK7ProteinHetionet hetionet:covaries:1022-23413Inferred only
NCS1 covaries with COPZ1ProteinHetionet hetionet:covaries:22818-23413Inferred only
NCS1 covaries with CRIPTProteinHetionet hetionet:covaries:23413-9419Inferred only
NCS1 covaries with CYP2D6ProteinHetionet hetionet:covaries:1565-23413Inferred only
NCS1 covaries with DDX39BProteinHetionet hetionet:covaries:23413-7919Inferred only

Show the remaining 36

DOC2B covaries with NCS1ProteinHetionet hetionet:covaries:23413-8447Inferred only
EDF1 covaries with NCS1ProteinHetionet hetionet:covaries:23413-8721Inferred only
NCS1 covaries with ELOBProteinHetionet hetionet:covaries:23413-6923Inferred only
NCS1 covaries with GLI4ProteinHetionet hetionet:covaries:23413-2738Inferred only
NCS1 covaries with HSPA9ProteinHetionet hetionet:covaries:23413-3313Inferred only
NCS1 covaries with IRX3ProteinHetionet hetionet:covaries:23413-79191Inferred only
NCS1 covaries with NDFIP1ProteinHetionet hetionet:covaries:23413-80762Inferred only
NCS1 covaries with OLFM3ProteinHetionet hetionet:covaries:118427-23413Inferred only
OR52B2 covaries with NCS1ProteinHetionet hetionet:covaries:23413-255725Inferred only
NCS1 covaries with PCDHB12ProteinHetionet hetionet:covaries:23413-56124Inferred only
NCS1 covaries with PELOProteinHetionet hetionet:covaries:23413-53918Inferred only
NCS1 covaries with POLR2GProteinHetionet hetionet:covaries:23413-5436Inferred only
NCS1 covaries with RHOCProteinHetionet hetionet:covaries:23413-389Inferred only
NCS1 covaries with RND2ProteinHetionet hetionet:covaries:23413-8153Inferred only
NCS1 covaries with RPL36ProteinHetionet hetionet:covaries:23413-25873Inferred only
NCS1 covaries with RPL36ALProteinHetionet hetionet:covaries:23413-6166Inferred only
NCS1 covaries with RPS26ProteinHetionet hetionet:covaries:23413-6231Inferred only
NCS1 covaries with SHISA4ProteinHetionet hetionet:covaries:149345-23413Inferred only
NCS1 covaries with SLC35E3ProteinHetionet hetionet:covaries:23413-55508Inferred only
NCS1 covaries with SSU72ProteinHetionet hetionet:covaries:23413-29101Inferred only
NCS1 covaries with STXBP2ProteinHetionet hetionet:covaries:23413-6813Inferred only
NCS1 covaries with UHMK1ProteinHetionet hetionet:covaries:127933-23413Inferred only
VAMP2 covaries with NCS1ProteinHetionet hetionet:covaries:23413-6844Inferred only
NCS1 covaries with ZNF319ProteinHetionet hetionet:covaries:23413-57567Inferred only
ZNF454 covaries with NCS1ProteinHetionet hetionet:covaries:23413-285676Inferred only
DRD2 interacts with NCS1ProteinHetionet hetionet:interacts:1813-23413Inferred only
DRD3 interacts with NCS1ProteinHetionet hetionet:interacts:1814-23413Inferred only
DRD5 interacts with NCS1ProteinHetionet hetionet:interacts:1816-23413Inferred only
NCS1 interacts with DTX2ProteinHetionet hetionet:interacts:113878-23413Inferred only
GRK2 interacts with NCS1ProteinHetionet hetionet:interacts:156-23413Inferred only
IL1RAPL1 interacts with NCS1ProteinHetionet hetionet:interacts:11141-23413Inferred only
KCND2 interacts with NCS1ProteinHetionet hetionet:interacts:23413-3751Inferred only
PI4KB interacts with NCS1ProteinHetionet hetionet:interacts:23413-5298Inferred only
UBC interacts with NCS1ProteinHetionet hetionet:interacts:23413-7316Inferred only
NCS1 regulates regulation of neuron projection developmentBiological processgene ontology P62166|GO:0010975Inferred only
NCS1 regulates regulation of signal transductionBiological processgene ontology P62166|GO:0009966Inferred only

Other names

6 names

Resolves to: NCS1

Also called: FLUPFREQFrequenin homologFrequenin-like proteinFrequenin-like ubiquitous proteinNCS-1

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