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Proteins/UNIPROT:O15020

SPTBN2

Protein·UNIPROT:O15020

Open in the graph

Probably plays an important role in neuronal membrane skeleton.

Function from UniProtKB (O15020), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

autosomal recessive spinocerebellar ataxia 14 has a germline basis in SPTBN2DiseaseGenCC HGNC:11276|MONDO:0014159Inferred only
spinocerebellar ataxia type 5 has a germline basis in SPTBN2DiseaseGenCC HGNC:11276|MONDO:0010848Inferred only

Statements

40 statements

40 statements · 3 reference databases · Subject: SPTBN2 · Sources: gene ontology, Hetionet, Reactome

Search this listOrder

DMRTA2 covaries with SPTBN2ProteinHetionet hetionet:covaries:63950-6712Inferred only
HOXA2 covaries with SPTBN2ProteinHetionet hetionet:covaries:3199-6712Inferred only
THPO covaries with SPTBN2ProteinHetionet hetionet:covaries:6712-7066Inferred only
YWHAQ covaries with SPTBN2ProteinHetionet hetionet:covaries:10971-6712Inferred only
ACTA1 interacts with SPTBN2ProteinHetionet hetionet:interacts:58-6712Inferred only
ACTB interacts with SPTBN2ProteinHetionet hetionet:interacts:60-6712Inferred only
SPTBN2 interacts with ACTR1AProteinHetionet hetionet:interacts:10121-6712Inferred only
APC interacts with SPTBN2ProteinHetionet hetionet:interacts:324-6712Inferred only
CELSR3 interacts with SPTBN2ProteinHetionet hetionet:interacts:1951-6712Inferred only
DCTN1 interacts with SPTBN2ProteinHetionet hetionet:interacts:1639-6712Inferred only
SPTBN2 interacts with MINK1ProteinHetionet hetionet:interacts:50488-6712Inferred only
SPTBN2 interacts with SIRT7ProteinHetionet hetionet:interacts:51547-6712Inferred only

Show the remaining 28

SPTA1 interacts with SPTBN2ProteinHetionet hetionet:interacts:6708-6712Inferred only
SPTBN2 interacts with UBCProteinHetionet hetionet:interacts:6712-7316Inferred only
SPTBN2 interacts with UNC13BProteinHetionet hetionet:interacts:10497-6712Inferred only
SPTBN2 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
SPTBN2 participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
SPTBN2 participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
SPTBN2 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
SPTBN2 participates in COPI-mediated anterograde transportPathwayReactome R-HSA-6807878Inferred only
SPTBN2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SPTBN2 participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
SPTBN2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
SPTBN2 participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
SPTBN2 participates in Interaction between L1 and AnkyrinsPathwayReactome R-HSA-445095Inferred only
SPTBN2 participates in L1CAM interactionsPathwayReactome R-HSA-373760Inferred only
SPTBN2 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
SPTBN2 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
SPTBN2 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
SPTBN2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SPTBN2 participates in MHC class II antigen presentationPathwayReactome R-HSA-2132295Inferred only
SPTBN2 participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
SPTBN2 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
SPTBN2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
SPTBN2 participates in Processing of antigen in germinal center B cellsPathwayReactome R-HSA-9979719Inferred only
SPTBN2 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
SPTBN2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SPTBN2 participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
SPTBN2 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
SPTBN2 regulates regulation of postsynaptic specialization assemblyBiological processgene ontology O15020|GO:0099150Inferred only

Other names

4 names

Resolves to: SPTBN2

Also called: Beta-III spectrinKIAA0302SCA5Spinocerebellar ataxia 5 protein

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