Proteins/UNIPROT:P06753

TPM3

ProteinUNIPROT:P06753

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments..

Function from UniProtKB (P06753), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

8 rows

cap myopathy has a germline basis in TPM3DiseaseGenCC HGNC:12012|MONDO:0015753Inferred only
childhood-onset nemaline myopathy has a germline basis in TPM3DiseaseGenCC HGNC:12012|MONDO:0015738Inferred only
congenital fiber-type disproportion myopathy has a germline basis in TPM3DiseaseGenCC HGNC:12012|MONDO:0009711Inferred only
congenital generalized hypercontractile muscle stiffness syndrome has a germline basis in TPM3DiseaseGenCC HGNC:12012|MONDO:0018780Inferred only
congenital myopathy 4A, autosomal dominant has a germline basis in TPM3DiseaseGenCC HGNC:12012|MONDO:0800341Inferred only
congenital myopathy 4B, autosomal recessive has a germline basis in TPM3DiseaseGenCC HGNC:12012|MONDO:0012239Inferred only
intermediate nemaline myopathy has a germline basis in TPM3DiseaseGenCC HGNC:12012|MONDO:0015736Inferred only
TPM3-related myopathy has a germline basis in TPM3DiseaseGenCC HGNC:12012|MONDO:0100108Inferred only

Statements

140 statements

140 statements · 3 reference databases · Subject: TPM3 · Sources: Hetionet, Reactome, WikiPathways

Order

ABCA2 covaries with TPM3ProteinHetionet hetionet:covaries:20-7170Inferred only
ADRA1D covaries with TPM3ProteinHetionet hetionet:covaries:146-7170Inferred only
AIP covaries with TPM3ProteinHetionet hetionet:covaries:7170-9049Inferred only
ARHGAP35 covaries with TPM3ProteinHetionet hetionet:covaries:2909-7170Inferred only
ASCL2 covaries with TPM3ProteinHetionet hetionet:covaries:430-7170Inferred only
ASPDH covaries with TPM3ProteinHetionet hetionet:covaries:554235-7170Inferred only
BSX covaries with TPM3ProteinHetionet hetionet:covaries:390259-7170Inferred only
C11orf96 covaries with TPM3ProteinHetionet hetionet:covaries:387763-7170Inferred only
C15orf62 covaries with TPM3ProteinHetionet hetionet:covaries:643338-7170Inferred only
C1QL4 covaries with TPM3ProteinHetionet hetionet:covaries:338761-7170Inferred only
CABP7 covaries with TPM3ProteinHetionet hetionet:covaries:164633-7170Inferred only
CBLN2 covaries with TPM3ProteinHetionet hetionet:covaries:147381-7170Inferred only

Show the remaining 128

CDK14 covaries with TPM3ProteinHetionet hetionet:covaries:5218-7170Inferred only
CLEC2L covaries with TPM3ProteinHetionet hetionet:covaries:154790-7170Inferred only
CORO1A covaries with TPM3ProteinHetionet hetionet:covaries:11151-7170Inferred only
COX6A2 covaries with TPM3ProteinHetionet hetionet:covaries:1339-7170Inferred only
CRIP1 covaries with TPM3ProteinHetionet hetionet:covaries:1396-7170Inferred only
CTSA covaries with TPM3ProteinHetionet hetionet:covaries:5476-7170Inferred only
CYP46A1 covaries with TPM3ProteinHetionet hetionet:covaries:10858-7170Inferred only
CYSRT1 covaries with TPM3ProteinHetionet hetionet:covaries:375791-7170Inferred only
DDR1 covaries with TPM3ProteinHetionet hetionet:covaries:7170-780Inferred only
DGKK covaries with TPM3ProteinHetionet hetionet:covaries:139189-7170Inferred only
DNTTIP1 covaries with TPM3ProteinHetionet hetionet:covaries:116092-7170Inferred only
DUSP15 covaries with TPM3ProteinHetionet hetionet:covaries:128853-7170Inferred only
DVL2 covaries with TPM3ProteinHetionet hetionet:covaries:1856-7170Inferred only
EGR3 covaries with TPM3ProteinHetionet hetionet:covaries:1960-7170Inferred only
EHD2 covaries with TPM3ProteinHetionet hetionet:covaries:30846-7170Inferred only
EIF6 covaries with TPM3ProteinHetionet hetionet:covaries:3692-7170Inferred only
FANCD2OS covaries with TPM3ProteinHetionet hetionet:covaries:115795-7170Inferred only
FRAT2 covaries with TPM3ProteinHetionet hetionet:covaries:23401-7170Inferred only
FSCN2 covaries with TPM3ProteinHetionet hetionet:covaries:25794-7170Inferred only
GAL3ST2 covaries with TPM3ProteinHetionet hetionet:covaries:64090-7170Inferred only
GOLGB1 covaries with TPM3ProteinHetionet hetionet:covaries:2804-7170Inferred only
GREM1 covaries with TPM3ProteinHetionet hetionet:covaries:26585-7170Inferred only
H2AC11; H2AC13; H2AC15; H2AC16; H2AC17 covaries with TPM3ProteinHetionet hetionet:covaries:7170-8330Inferred only
H2BC15 covaries with TPM3ProteinHetionet hetionet:covaries:7170-8341Inferred only
HOXA1 covaries with TPM3ProteinHetionet hetionet:covaries:3198-7170Inferred only
ISYNA1 covaries with TPM3ProteinHetionet hetionet:covaries:51477-7170Inferred only
KCTD11 covaries with TPM3ProteinHetionet hetionet:covaries:147040-7170Inferred only
KCTD19 covaries with TPM3ProteinHetionet hetionet:covaries:146212-7170Inferred only
KRTAP24-1 covaries with TPM3ProteinHetionet hetionet:covaries:643803-7170Inferred only
LHFPL3 covaries with TPM3ProteinHetionet hetionet:covaries:375612-7170Inferred only
MBD5 covaries with TPM3ProteinHetionet hetionet:covaries:55777-7170Inferred only
MCRIP1 covaries with TPM3ProteinHetionet hetionet:covaries:348262-7170Inferred only
MEF2D covaries with TPM3ProteinHetionet hetionet:covaries:4209-7170Inferred only
MEIOC covaries with TPM3ProteinHetionet hetionet:covaries:284071-7170Inferred only
MRGPRF covaries with TPM3ProteinHetionet hetionet:covaries:116535-7170Inferred only
NCOA1 covaries with TPM3ProteinHetionet hetionet:covaries:7170-8648Inferred only
NCOA2 covaries with TPM3ProteinHetionet hetionet:covaries:10499-7170Inferred only
NDN covaries with TPM3ProteinHetionet hetionet:covaries:4692-7170Inferred only
NEUROD4 covaries with TPM3ProteinHetionet hetionet:covaries:58158-7170Inferred only
NF2 covaries with TPM3ProteinHetionet hetionet:covaries:4771-7170Inferred only
NHERF2 covaries with TPM3ProteinHetionet hetionet:covaries:7170-9351Inferred only
NKX3-2 covaries with TPM3ProteinHetionet hetionet:covaries:579-7170Inferred only
NWD2 covaries with TPM3ProteinHetionet hetionet:covaries:57495-7170Inferred only
OPN1LW covaries with TPM3ProteinHetionet hetionet:covaries:5956-7170Inferred only
OR4D5 covaries with TPM3ProteinHetionet hetionet:covaries:219875-7170Inferred only
OR52H1 covaries with TPM3ProteinHetionet hetionet:covaries:390067-7170Inferred only
OR52W1 covaries with TPM3ProteinHetionet hetionet:covaries:120787-7170Inferred only
OR6S1 covaries with TPM3ProteinHetionet hetionet:covaries:341799-7170Inferred only
PCP2 covaries with TPM3ProteinHetionet hetionet:covaries:126006-7170Inferred only
PEX12 covaries with TPM3ProteinHetionet hetionet:covaries:5193-7170Inferred only
POLD1 covaries with TPM3ProteinHetionet hetionet:covaries:5424-7170Inferred only
POU3F4 covaries with TPM3ProteinHetionet hetionet:covaries:5456-7170Inferred only
PPP1R9B covaries with TPM3ProteinHetionet hetionet:covaries:7170-84687Inferred only
TPM3 covaries with PRPF3ProteinHetionet hetionet:covaries:7170-9129Inferred only
PTGR3 covaries with TPM3ProteinHetionet hetionet:covaries:284273-7170Inferred only
TPM3 covaries with PTPRUProteinHetionet hetionet:covaries:10076-7170Inferred only
RAB24 covaries with TPM3ProteinHetionet hetionet:covaries:53917-7170Inferred only
RHBDL1 covaries with TPM3ProteinHetionet hetionet:covaries:7170-9028Inferred only
SBSPON covaries with TPM3ProteinHetionet hetionet:covaries:157869-7170Inferred only
SLC2A11 covaries with TPM3ProteinHetionet hetionet:covaries:66035-7170Inferred only
SLC35F5 covaries with TPM3ProteinHetionet hetionet:covaries:7170-80255Inferred only
SNRNP200 covaries with TPM3ProteinHetionet hetionet:covaries:23020-7170Inferred only
SP7 covaries with TPM3ProteinHetionet hetionet:covaries:121340-7170Inferred only
STAC3 covaries with TPM3ProteinHetionet hetionet:covaries:246329-7170Inferred only
STMN4 covaries with TPM3ProteinHetionet hetionet:covaries:7170-81551Inferred only
SYT11 covaries with TPM3ProteinHetionet hetionet:covaries:23208-7170Inferred only
TAF1 covaries with TPM3ProteinHetionet hetionet:covaries:6872-7170Inferred only
TAF6 covaries with TPM3ProteinHetionet hetionet:covaries:6878-7170Inferred only
TPM3 covaries with TAL1ProteinHetionet hetionet:covaries:6886-7170Inferred only
TBKBP1 covaries with TPM3ProteinHetionet hetionet:covaries:7170-9755Inferred only
TPM3 covaries with TCEANC2ProteinHetionet hetionet:covaries:127428-7170Inferred only
TDRD7 covaries with TPM3ProteinHetionet hetionet:covaries:23424-7170Inferred only
TEAD2 covaries with TPM3ProteinHetionet hetionet:covaries:7170-8463Inferred only
THSD7B covaries with TPM3ProteinHetionet hetionet:covaries:7170-80731Inferred only
TIGD7 covaries with TPM3ProteinHetionet hetionet:covaries:7170-91151Inferred only
TIMM13 covaries with TPM3ProteinHetionet hetionet:covaries:26517-7170Inferred only
TMUB1 covaries with TPM3ProteinHetionet hetionet:covaries:7170-83590Inferred only
TRIM17 covaries with TPM3ProteinHetionet hetionet:covaries:51127-7170Inferred only
TRIM68 covaries with TPM3ProteinHetionet hetionet:covaries:55128-7170Inferred only
TSC22D4 covaries with TPM3ProteinHetionet hetionet:covaries:7170-81628Inferred only
TPM3 covaries with TSSK3ProteinHetionet hetionet:covaries:7170-81629Inferred only
TSSK6 covaries with TPM3ProteinHetionet hetionet:covaries:7170-83983Inferred only
UPK1B covaries with TPM3ProteinHetionet hetionet:covaries:7170-7348Inferred only
VANGL2 covaries with TPM3ProteinHetionet hetionet:covaries:57216-7170Inferred only
TPM3 covaries with VWA1ProteinHetionet hetionet:covaries:64856-7170Inferred only
TPM3 covaries with WASF2ProteinHetionet hetionet:covaries:10163-7170Inferred only
WBP2 covaries with TPM3ProteinHetionet hetionet:covaries:23558-7170Inferred only
WDR45 covaries with TPM3ProteinHetionet hetionet:covaries:11152-7170Inferred only
WNT9A covaries with TPM3ProteinHetionet hetionet:covaries:7170-7483Inferred only
XKR6 covaries with TPM3ProteinHetionet hetionet:covaries:286046-7170Inferred only
YTHDC2 covaries with TPM3ProteinHetionet hetionet:covaries:64848-7170Inferred only
ZIC1 covaries with TPM3ProteinHetionet hetionet:covaries:7170-7545Inferred only
ZKSCAN8 covaries with TPM3ProteinHetionet hetionet:covaries:7170-7745Inferred only
TPM3 covaries with ZNF436ProteinHetionet hetionet:covaries:7170-80818Inferred only
ZNF655 covaries with TPM3ProteinHetionet hetionet:covaries:7170-79027Inferred only
ZSWIM6 covaries with TPM3ProteinHetionet hetionet:covaries:57688-7170Inferred only
ACTA1 interacts with TPM3ProteinHetionet hetionet:interacts:58-7170Inferred only
ACTB interacts with TPM3ProteinHetionet hetionet:interacts:60-7170Inferred only
CNN1 interacts with TPM3ProteinHetionet hetionet:interacts:1264-7170Inferred only
TPM3 interacts with KXD1ProteinHetionet hetionet:interacts:7170-79036Inferred only
S100A2 interacts with TPM3ProteinHetionet hetionet:interacts:6273-7170Inferred only
S100A4 interacts with TPM3ProteinHetionet hetionet:interacts:6275-7170Inferred only
SMAD3 interacts with TPM3ProteinHetionet hetionet:interacts:4088-7170Inferred only
TPM3 interacts with SUMO4ProteinHetionet hetionet:interacts:387082-7170Inferred only
TPM3 interacts with TFPTProteinHetionet hetionet:interacts:29844-7170Inferred only
TMOD1 interacts with TPM3ProteinHetionet hetionet:interacts:7111-7170Inferred only
TPM3 interacts with TMOD2ProteinHetionet hetionet:interacts:29767-7170Inferred only
TPM3 participates in Caffeine in myocytesPathwayWikiPathways WP5603Inferred only
TPM3 participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
TPM3 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
TPM3 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
TPM3 participates in Mammary gland development pregnancy and lactation stage 3 of 4PathwayWikiPathways WP2817Inferred only
TPM3 participates in miR targeted genes in leukocytesPathwayWikiPathways WP2003Inferred only
TPM3 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
TPM3 participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
TPM3 participates in miR targeted genes in squamous cellPathwayWikiPathways WP2006Inferred only
TPM3 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
TPM3 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
TPM3 participates in RHOV GTPase cyclePathwayReactome R-HSA-9013424Inferred only
TPM3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TPM3 participates in Signaling by ALK fusions and activated point mutantsPathwayReactome R-HSA-9725370Inferred only
TPM3 participates in Signaling by ALK in cancerPathwayReactome R-HSA-9700206Inferred only
TPM3 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
TPM3 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
TPM3 participates in Smooth Muscle ContractionPathwayReactome R-HSA-445355Inferred only
TPM3 participates in Striated Muscle ContractionPathwayReactome R-HSA-390522Inferred only
TPM3 participates in Striated muscle contraction pathwayPathwayWikiPathways WP383Inferred only
TPM3 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only

Other names

4 names

Resolves to: TPM3

Also called: Gamma-tropomyosinhTM5Tropomyosin-3Tropomyosin-5

← Every protein Find it in the graph →