Proteins/UNIPROT:Q96M96

FGD4

ProteinUNIPROT:Q96M96

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)..

Function from UniProtKB (Q96M96), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

Charcot-Marie-Tooth disease has a germline basis in FGD4DiseaseGenCC HGNC:19125|MONDO:0015626Inferred only
Charcot-Marie-Tooth disease type 4H has a germline basis in FGD4DiseaseGenCC HGNC:19125|MONDO:0012250Inferred only

Statements

19 statements

19 statements · 4 reference databases · Subject: FGD4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ACTA1 interacts with FGD4ProteinHetionet hetionet:interacts:121512-58Inferred only
FGD4 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
FGD4 participates in Cell death signalling via NRAGE, NRIF and NADEPathwayReactome R-HSA-204998Inferred only
FGD4 participates in Death Receptor SignalingPathwayReactome R-HSA-73887Inferred only
FGD4 participates in G alpha (12/13) signalling eventsPathwayReactome R-HSA-416482Inferred only
FGD4 participates in Glucocorticoid receptor pathwayPathwayWikiPathways WP2880Inferred only
FGD4 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
FGD4 participates in Intracellular trafficking proteins involved in CMT neuropathyPathwayWikiPathways WP4856Inferred only
FGD4 participates in NRAGE signals death through JNKPathwayReactome R-HSA-193648Inferred only
FGD4 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
FGD4 participates in p75 NTR receptor-mediated signallingPathwayReactome R-HSA-193704Inferred only
FGD4 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only

Show the remaining 7

FGD4 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FGD4 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
FGD4 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
FGD4 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
FGD4 regulates regulation of cell shapeBiological processgene ontology Q96M96|GO:0008360Inferred only
FGD4 regulates regulation of GTPase activityBiological processgene ontology Q96M96|GO:0043087Inferred only
FGD4 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q96M96|GO:0051056Inferred only

Other names

5 names

Resolves to: FGD4

Also called: Actin filament-binding protein frabinFGD1-related F-actin-binding proteinFRABPZFYVE6Zinc finger FYVE domain-containing protein 6

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